颗粒状β-磷酸三钙复合骨形态发生蛋白2修复齿槽裂骨缺损  

Application of bone morphogenetic protein-2 combined with granulo-β-tricalcium phosphate in alveolar cleft reconstruction

作　　者：王思明[1] 孙媛[1] 

机构地区：[1]连云港市第二人民医院口腔科,江苏省连云港市222023

出　　处：《中国组织工程研究与临床康复》2011年第51期9687-9690,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:齿槽裂的修复已成为唇腭裂序列治疗中的一个重要环节。以人工骨为载体进行优化组合制成具有高度骨诱导活性的复合人工骨,极大地提高了临床上骨缺损修复的治疗效果。目的:观察β-磷酸三钙复合骨形态发生蛋白2修复齿槽裂的效果。方法:选择连云港市第二人民医院口腔科收治的齿槽裂患者24例,随机分为实验组和对照组,实验组应用骨形态发生蛋白2/β-磷酸三钙复合物修复齿槽裂,对照组应用自体髂骨松质骨修复。结果与结论:两组切口均一期愈合,无植入物排出。随访时间3～12个月,修复后3个月X射线可见局部骨性愈合,修复后1年实验组人工骨部分被自体骨取代,骨吸收不明显,而对照组骨吸收明显。Enemar等分级标准评估实验组Ⅰ级疗效率为84%,对照组Ⅰ级疗效率为17%,两组相比差异有显著性意义(P<0.05)。提示颗粒状β-磷酸三钙复合骨形态发生蛋白2修复齿槽裂,具有恢复形态准确,修复创伤小的优点;植入物组织相容性好,具有骨引导性,可降解,能被自体骨完全取代,且无不良反应,是一种良好的齿槽裂修复方法。BACKGROUND：Repair of alveolar cleft is an important part of treatment of cleft lip and palate.Composite artificial bone prepared by optimal combination based on the carrier of artificial bone has a highly osteoinductive activity and can greatly improve the treatment effect in repair of bone defects in clinic.OBJECTIVE：To evaluate the combined effects of bone morphogenetic protein-2（BMP-2） and β-tricalcium phosphate（β-TCP） in alveolar cleft reconstruction.METHODS：Twenty-four alveolar cleft patients from Department of Stomatology,Lianyungang Second People＇s Hospital were divided into experimental group and control group randomly.The experimental group was repaired with BMP-2/β-TCP.The control group was repaired with autogenous iliac cancellous bone.RESULTS AND CONCLUSION：Incisions in both groups were with primary healing and without implant extrusion.All of the patients were followed-up for 3-6 months.Three months after surgery,bone concrescence was seen on X-ray.Part of the artificial bone was replaced by autologous bone and the bone resorption was not obvious in the experimental group after 1 year of surgery,while the bone resorption in the control group was obvious.Enemar grading standard showed that the efficacy rates of grade Ⅰ in the experimental group and control group were 84% and 17% respectively,and the difference was significant（P 0.05）.It is indicated that the granulo-β-TCP/BMP-2 has the advantages of an accurate shape recovery and a low repair trauma in alveolar cleft reconstruction;the implant has a good biocompatibility,osteocondutibility and degradability,so as can be completely replaced by autologous bone and well used in alveolar cleft reconstruction.

关 键 词：齿槽裂 修复 Β-磷酸三钙 骨形态发生蛋白2 骨缺损 

分 类 号：R318[医药卫生—生物医学工程]