电针抑制骨性关节炎的炎症反应及延缓关节软骨退变  

Electro-acupuncture treatment inhibits inflammatory reaction and postpones articular cartilage degeneration in osteoarthritis

作　　者：吴明霞[1] 李西海[2] 吴广文[2] 李俐[1] 陈文列 刘献祥[3] 

机构地区：[1]福建中医药大学附属第二人民医院针灸科,福建省福州市350003 [2]福建中医药大学中西医结合研究院,福建省福州市350003 [3]福建省中西医结合老年性疾病重点实验室,福建省福州市350108

出　　处：《中国组织工程研究与临床康复》2011年第50期9410-9414,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金(30873277),课题名称:温针干预兔软骨退变的信号转导机制研究;陈可冀中西医结合发展基金(CKJ2008003),课题名称:温针对兔软骨退变信号转导机制影响的研究~~

摘　　要：背景:研究表明电针能有效缓解骨性关节炎的临床症状。目的:观察电针抑制骨性关节炎的炎症反应及保护关节软骨的作用机制。方法:采用木瓜蛋白酶双膝关节腔注射复制SD大鼠骨性关节炎模型,建模成功后分别电针内、外膝眼(EX-LE4,EX-LE5)治疗5,15,30min/d。结果与结论:与模型组比较,经电针15,30min/d治疗的骨性关节炎模型大鼠血液中P物质及关节液中白细胞介素1、白细胞介素6、肿瘤坏死因子α和基质金属蛋白酶3的质量浓度明显减少(P<0.05),血液中瘦素及关节液中基质金属蛋白酶抑制因子1的水平明显增加(P<0.05),同时软骨退变的程度明显减轻(P<0.05,P<0.01)。证实电针能有效减轻大鼠膝骨性关节炎的炎症反应,延缓关节软骨的退变。BACKGROUND： Several studies have shown that electro-acupuncture （EA） can effectively alleviate the clinical symptoms of osteoarthritis. OBJECTIVE： To investigate the mechanism by which EA treatment inhibits osteoarthritis inflammation and protects the function of articular cartilage. METHODS： SD rat models of osteoarthritis were established by double knee joint cavity injection of papain. Osteoarthritis rat models were treated with EA at EX-LE4 and EX-LE5 for 5, 15 and 30 minutes per day. RESULTS AND CONCLUSION： Compared with the model group, substance P in blood and interleukin 1, interleukin 6, tumor necrosis factor a, matrix metalloproteinase 3 concentrations in synovial fluid were significantly reduced, leptin in blood and matrix metalloproteinase 1 in synovial fluid were significantly increased （P 〈 0.05）, and the degree of cartilage degeneration was significantly alleviated （P 〈 0.05, P 〈 0.01） in osteoarthritis rat models after treatment with EA for 15 and 30 minutes per day （P 〈 0.05）. These results showed that EA can effectively alleviate the inflammatory reaction and postpone articular cartilage degeneration in osteoarthritis.

关 键 词：骨性关节炎 电针 细胞因子 关节软骨 退变:骨组织构建 

分 类 号：R318[医药卫生—生物医学工程]