胰岛再生源蛋白(Reg)在组织修复中的功能和调控机制  

Functions and Underlying Mechanisms of Regenerating Islet-derived Proteins in Tissue Repair

作　　者：蒋子威[1] 李长伟[1] 雷虎[1] 全艳春[1] 赖玉平[1] 

机构地区：[1]华东师范大学生命科学学院微生物与免疫学实验室,上海200241

出　　处：《中国细胞生物学学报》2012年第1期1-10,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(No.81072422;No.31170867);上海市科委(No.11QA1401900)资助项目~~

摘　　要：胰岛再生源蛋白(regenerating islet-derived protein,Reg)是一个多功能分子,在多种生理、病理活动中发挥重要作用。该文主要综述Reg蛋白在组织损伤后促进细胞增殖、抑制炎症因子过表达、调控细胞凋亡和抑制病原微生物生长和扩散的功能及调控机制,为治疗组织损伤提供新思路和新途径。Regenerating islet-derived protein （Reg） is a multi-functional molecule and plays an important role in several physiological and pathological reactions. Here we focus on functions of Reg in tissue repair and discuss how Reg induces cell proliferation, regulates excessive inflammation or cell apoptosis, and inhibits pathogen growth and diffusion. Furthmore, we summarize the underlying mechanisms by which Reg responses to tissue injury. Our review provides new insights into pathways contributing to tissue repair, and may ultimately lead to the development of new forms of treatment.

关 键 词：胰岛再生源蛋白 组织修复 细胞增殖 抑制炎症 抑制细菌 

分 类 号：R96[医药卫生—药理学]