盐酸马尼地平片治疗轻中度原发性高血压的疗效和安全性  

Efficacy and safety of manidipine tablets in treatment of mild to moderate hypertension

作　　者：肖洁[1] 赵秀丽[1] 周辉[1] 王建旗[1] 郑华[1] 李嘉静[1] 王淑民[1] 武峰[1] 郭韶洁[1] 

机构地区：[1]首都医科大学附属北京同仁医院,北京100730

出　　处：《中国临床药理学杂志》2012年第1期13-15,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价盐酸马尼地平片治疗轻中度原发性高血压的疗效和安全性。方法用随机双盲对照研究,设苯磺酸氨氯地平片为对照药物。随机入选病人共60例但脱落1例完成59例,马尼地平组30例,苯磺酸氨氯地平组29例。2组每天分别服用盐酸马尼地平片10～20 mg和苯磺酸氨氯地平片5～10 mg,两药均为每日1次,共8周。结果治疗8周后,盐酸马尼地平片组收缩压和舒张压分别下降(8.70±13.11)mmHg和(7.90±5.54)mmHg,苯磺酸氨氯地平片组分别下降为(13.28±13.40)mmHg和(11.66±7.66)mmHg,与治疗前相比均有统计学意义(均P<0.05)。2组均无严重不良事件发生。结论盐酸马尼地平片每日服用1次,可显著地、平稳地降低血压,患者耐受性较好。Objective To study the efficacy and safety of manidipine in treatment of mild to moderate hypertension.Methods The clinical trial were randomized,double blind and amlodipine besylate controlled.Fifty-nine patients,manidipine group 30 patients,amlodipine besylate group 29 patients.One group was treated with manidipine 10-20 mg·d-1,and the other group with amlodipine besylate 5-10 mg·d-1,for 8 weeks.Results After 8 weeks treatment,systolic and diastolic blood pressure decreased（8.70±13.11） mmHg and（7.90±5.5） mmHg（P0.05） in manidipine group,while（13.28 ± 13.40） mmHg and（11.66±7.66） mmHg in amlodipine besylate group,all of them have statistical significance（P0.05）.No serious adverse events occurred in two groups.Conclusion Manidipine once daily can remarkably reduce blood pressure,the patient′s tolerant was well.

关 键 词：高血压 盐酸马尼地平片 苯磺酸氨氯地平 

分 类 号：R544.1[医药卫生—心血管疾病] R972.4[医药卫生—内科学]