Chemerin与糖脂代谢关系的研究进展  

Progress on the relationship between chemerin and glucose and lipid metabolism

作　　者：李静[1,2] 左笑丛[1,2] 

机构地区：[1]中南大学湘雅三医院药剂科,长沙410013 [2]中南大学药学院,长沙410013

出　　处：《中国临床药理学杂志》2012年第1期72-74,共3页The Chinese Journal of Clinical Pharmacology

基　　金：湖南省自然科学基金资助项目(09JJ5035);湖南省卫生厅基金资助项目(B2010-034)

摘　　要：Chemerin是新发现的一种脂肪因子,在脂肪组织中高度表达,它能通过自分泌途径,作用于自身受体CMKLR1,促进脂肪细胞分化及葡萄糖转运,并可通过自分泌或旁分泌途径,对脂肪组织及脂质代谢产生一系列影响。近期研究发现,Chemerin除具有炎症因子的趋化作用外,还与肥胖、胰岛素抵抗和代谢综合征有密切关系。Chemerin,a novel adipokine,expressed highly by adipocyte,promotes adipocyte differentiation and glucose transport of adipocyte via its own receptor CMKLR1.Chemerin influences adipose tissue and lipid metabolism through the autocrine and paracrine ways.The recent researcher found that chemerin not only has chemotactic function of inflammation factors but also has close relationship with obesity,insulin resistance and metabolic syndrome.Therefore chemerin plays an important role in airframe glucose and lipid metabolism.

关 键 词：CHEMERIN 脂肪因子 糖脂代谢 肥胖 代谢综合征 

分 类 号：R969.1[医药卫生—药理学] R977[医药卫生—药学]