肉桂油对胰岛素抵抗小鼠糖脂代谢的影响  

Effect of volatile oil from Cinnamomi Cortex on blood glucose and lipid metabolism in insulin-resistant mice

作　　者：陈璿瑛[1] 彭小平[2] 王琳[1] 魏筱华[1] 李文娟[3] 何明[4] 

机构地区：[1]南昌大学第一附属医院药剂科,江西省南昌市330006 [2]南昌大学第一附属医院心内科,江西省南昌市330006 [3]南昌大学食品科学与技术国家重点实验室,江西省南昌市330047 [4]南昌大学药学院,江西省南昌市330006

出　　处：《世界华人消化杂志》2011年第33期3441-3445,共5页World Chinese Journal of Digestology

基　　金：江西省卫生厅课题基金资助项目;No.20093040

摘　　要：目的:研究肉桂油对胰岛素抵抗小鼠糖脂代谢的影响,探讨其作用机制.方法:采用高脂饲料喂养建立小鼠胰岛素抵抗模型,经肉桂油治疗后测定口服糖耐量及胰岛素耐受,观察体质量、血糖、血清胰岛素、甘油三酯、总胆固醇、瘦素、抵抗素、脂联素的变化.结果:肉桂油能降低胰岛素抵抗小鼠的体质量(30.3±3.6vs34.6±3.1,P<0.05)、血糖(7.6±2.2vs9.2±1.3,P<0.05)、血清胰岛素(1.3±0.1vs1.7±0.2,P<0.05)、甘油三酯(70.1±10.9vs65.4±19.5,P<0.05)、总胆固醇(93.2±13.8vs102.3±21.5,P<0.05)、瘦素、抵抗素水平,同时改善口服糖耐量,降低胰岛素抵抗.结论:肉桂油能有效改善胰岛素抵抗小鼠糖脂代谢,其作用与降低血清瘦素、抵抗素水平,增加胰岛素敏感性有关.AIM： To investigate the effect of volatile oil from Cinnamomi Cortex （VOCC） on blood glucose and lipid metabolism in insulin-resistant mice and to investigate the possible mechanisms involved. METHODS： Insulin resistance was induced by feeding a high-fat diet. After insulin-resistant mice were treated orally with VOCC, oral glu-cose tolerance test and insulin tolerance test were performed. The body weight, blood glucose, serum insulin, total cholesterol, triglyceride, leptin, resistin, and adiponectin were determined using biochemical methods. RESULTS： VOCC administration decreased body weight gain （30.3 ± 3.6 vs 34.6 ± 3.1, P 0.05）, blood glucose （7.6 ± 2.2 vs 9.2 ± 1.3, P 0.05）, serum insulin （1.3 ± 0.1 vs 1.7 ± 0.2, P 0.05）, total cholesterol （70.1 ± 10.9 vs 65.4 ± 19.5, P 0.05）, triglyceride （93.2 ± 13.8 vs 102.3 ± 21.5, P 0.05）, leptin, and resistin levels. Treatment with VOCC also decreased insulin resistance by improving oral glucose tolerance and insulin tolerance. CONCLUSION： VOCC improved blood glucose and lipid metabolism by reducing serum leptin and resistin in insulin-resistant mice, thereby enhancing insulin sensitivity.

关 键 词：肉桂油 胰岛素抵抗 降糖降脂作用 瘦素 抵抗素 

分 类 号：R285.5[医药卫生—中药学]