Needling at the Waiguan (SJ5) in healthy limbs deactivated functional brain areas in ischemic stroke patients A functional magnetic resonance imaging study  

作　　者：Yong Huang Huiling Xiao Junqi Chen Shanshan Qu Yu Zheng Yangjia Lu Xinsheng Lai 

机构地区：[1]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, Guangdong Province, China [2]Department of Acupuncture and Massage, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510407, Guangdong Province, China

出　　处：《Neural Regeneration Research》2011年第36期2829-2833,共5页中国神经再生研究（英文版）

基　　金：the National Basic Research Program of China (973 Program), No. 2006CB504505, 2012CB518504;the 3 re Key Construction Program of "211 Project" of Guangdong Province

摘　　要：Deactivation is common in cerebral functional imaging. However, the physiological mechanisms responsible for this phenomenon remain poorly understood. The present study analyzed 12 ischemic stroke patients, who were randomly assigned to two groups： one group underwent sham needling and true needling at the Waiguan （SJ 5） in the healthy upper limb and the other group underwent sham and true needling at a sham point. Functional magnetic resonance imaging results showed no activation points in brain tissues following needling at SJ 5. However, compared with sham needling at SJ 5, true needling at SJ 5 deactivated Broadmann 4, 6, 24, and 32 areas. In addition, compared to needling at the sham point, true needling at SJ 5 deactivated bilateral hypothalamus. Results demonstrated that SJ 5 needling in the healthy upper limb resulted in specific directional brain action, as manifested by deactivation of cerebral areas related to motor （Broadmann 4 and 6）, emotion （hypothalamus）, and cognition （Broadmann 24, 32）.Deactivation is common in cerebral functional imaging. However, the physiological mechanisms responsible for this phenomenon remain poorly understood. The present study analyzed 12 ischemic stroke patients, who were randomly assigned to two groups： one group underwent sham needling and true needling at the Waiguan （SJ 5） in the healthy upper limb and the other group underwent sham and true needling at a sham point. Functional magnetic resonance imaging results showed no activation points in brain tissues following needling at SJ 5. However, compared with sham needling at SJ 5, true needling at SJ 5 deactivated Broadmann 4, 6, 24, and 32 areas. In addition, compared to needling at the sham point, true needling at SJ 5 deactivated bilateral hypothalamus. Results demonstrated that SJ 5 needling in the healthy upper limb resulted in specific directional brain action, as manifested by deactivation of cerebral areas related to motor （Broadmann 4 and 6）, emotion （hypothalamus）, and cognition （Broadmann 24, 32）.

关 键 词：acupuncture cerebral functional imaging Chinese medicine functional MRI ischemic stroke Waiguan （SJ 5） neural regeneration 

分 类 号：Q426[生物学—神经生物学] TP391.41[生物学—生理学]