大鼠白念珠菌支气管肺感染时肺组织Toll样受体2的表达及意义  

TLR2 expression in rats with Candida albicans infection in lung

作　　者：林莉[1] 王莉[1] 周洋洋[1] 陈耀华[1] 孟新丽[1] 康健[1] 

机构地区：[1]中国医科大学第一临床医院呼吸内科呼吸疾病研究所,沈阳110001

出　　处：《中国真菌学杂志》2011年第6期337-340,349,共5页Chinese Journal of Mycology

摘　　要：目的探讨Toll样受体2(TLR2)在白念珠菌支气管肺感染大鼠肺组织模型中的表达及意义。方法建立白念珠菌支气管肺感染大鼠模型,观察感染后肺组织病理形态学改变,采用免疫组织化学法观察感染后不同时间(第3天、第7天)白念珠菌支气管肺感染大鼠肺组织TLR2的表达,并与未感染组进行比较。结果大鼠白念珠菌支气管肺感染后肺组织TLR2表达水平明显升高。结论白念珠菌支气管肺感染肺组织TLR2表达增高可能参与感染的炎症反应。Objective To explore the expression of TLR2 in rats with Candida albicans infection in lung.Method Rats model of Candida albicans infection in lung was set up and changes in pathology were observed.TLR2 expression in the tissues at different timepoints were also observed by immunohistochemical method.Results The expression of TLR2 in the lung of Candida albicans infected rats was significaltly higher than that in healthy rats.Conclusions Overexpression of TLR2 in Candida albicans infected rats may related to inflammatory reaction.

关 键 词：白念珠菌 感染 TOLL样受体2 

分 类 号：R379.4[医药卫生—病原生物学]