复方苦参注射液治疗化疗后药物性肝损害  

Effect of compound matrine injection on chemotherapeutic drug-induced liver injury

作　　者：石阳[1] 裘光贤 周兆春 崔舒晟[1] 

机构地区：[1]上海市黄浦区中心医院肿瘤科,上海200002

出　　处：《中国新药杂志》2012年第1期71-73,共3页Chinese Journal of New Drugs

摘　　要：目的:评价复方苦参注射液对化疗药物造成的药物性肝损害的治疗作用。方法:选取于本科化疗时出现肝损患者240例,随机分为2组,一组应用复方苦参注射液治疗,一组予以安慰剂治疗,治疗2周后,比较治疗前后肝功能的变化。结果:通过2周治疗,试验组有65例患者肝功能恢复,占50.78%;对照组42例肝功能恢复,占37.5%,两组间有统计学差异(P<0.05)。按肝损类型分类,肝细胞型肝损患者运用复方苦参注射液治疗后,治疗效果优于对照组,且有统计学差异(P<0.05),而胆汁淤积型肝损及混合型肝损治疗后两组间无统计学差异。结论:复方苦参注射液能有效保护肝细胞,对治疗药物性肝损具有一定的效果。Objective： To evaluate the therapeutical effect of compound matrine injection on chemothera- peutic drug-induced liver injury. Methods： A total of 240 patients clinically diagnosed as drug-induced liver injury in oncology department were randomized to receive either a compound matrine injection or a placebo for 2 weeks. Then, the hepatic functions between the compound matrine injection and placebo groups were compared. Results： After two weeks of treatment, there were 65 patients＇ liver function recoveried in experiment group, which accounted for 50.78%. There were 42 patients＇ liver function recoveried in control group, which accounted for 37.5%. According to the subtypes, the effective rate on hepatocellular type in compound matrine injection group was significantly superior to that in placebo group （P 〈 0.05） , but the effective rate on cholestatic type and mixed type was not significantly different from that in placebo group. Conclusion： Compound matrine injection has a hepatic protectire effect on chemotherapeutic drug-induced liver injury.

关 键 词：复方苦参注射液 药物性肝损害 化疗 

分 类 号：R273[医药卫生—中西医结合]