我院1999年1月-2011年9月鲍曼不动杆菌的分布及耐药性分析  

Distribution and Drug Resistance of Acinetobacter baumannii in Our Hospital during Jan.1999-Sept.2011

作　　者：李玉强[1] 万忠林 

机构地区：[1]河南平顶山市第一人民医院,河南平顶山467000 [2]河南平高集团有限公司医院,河南平顶山467000

出　　处：《中国药房》2012年第6期529-531,共3页China Pharmacy

摘　　要：目的:了解鲍曼不动杆菌(ABA)的分布及耐药性,为医院治疗和控制ABA提供依据。方法:将我院1999年1月-2011年9月临床分离的1110株ABA药敏试验结果,应用WHONET5.5软件进行统计学分析。结果:ABA在病原菌中的检出率为8.7%,ABA中多药耐药菌的检出率为54.3%;其感染主要发生于重症监护室和呼吸内科,痰和分泌物是检出ABA较多的标本;除多粘菌素B、阿米卡星、亚胺培南和头孢哌酮/舒巴坦外,ABA对大多数抗菌药物耐药率较高(>40%),且耐药性呈升高趋势。结论:ABA耐药现象严重,临床治疗时应按药敏试验结果选药;医院应加强对ABA的监测,预防和控制ABA在院内暴发流行。OBJECTIVE： To study distribution and drug resistance dynamics ofAcinetobacter baumannii （ABA）, and to provide reference for clinical treatment and infection control in our hospital. METHODS： The results of drug sensitivity test of isolated 1 110 strains of ABA were analyzed statistically using WHONET 5.5 software. RESULTS： ABA accounted for 8.7% of all the pathogens. The isolation rate of multi-drug resistant strains was 54.3% in ABA. ABA were mainly obtained from ICU ward and respiratory ward. Sputum and secretion were the most specimens of ABA. The resistance rates to the most antibiotics were very high （〉40%）, except polymyxin B, amikacin, imipenem and cefoperazone/sulbactam. Drug resistance was in a increasing tendency. CONCLUSIONS： The drug resistance of multi-drug resistant ABA is very serious. It is very important to select proper antibiotics according to the result of susceptibility tests. Hospital should strengthen the monitoring of multi-drug resistant ABA to prevent and control the outbreak and prevalence of nosocornial infections.

关 键 词：鲍曼不动杆菌 耐药性 抗菌药物 

分 类 号：R969.3[医药卫生—药理学] R446.5[医药卫生—药学]