脂肪注射移植后皮肤质地改善的研究  

Study on the Improvement of skin quality after fat tissue grafting: a animal studying

作　　者：祝顺武[1] 宋广滨[1] 徐学武[1] 刘国锋[1] 

机构地区：[1]哈尔滨医科大学附属第二医院整形美容科,黑龙江哈尔滨150086

出　　处：《中国美容医学》2012年第1期78-81,共4页Chinese Journal of Aesthetic Medicine

基　　金：中国博士后科学基金项目(20100471010);黑龙江省青年科学基金项目(QC2009C38);哈尔滨市科技创新人才研究专项基金(2010RFQXS081)

摘　　要：目的:通过皮下脂肪注射移植,探索移植脂肪对皮肤质地的改善作用。方法:取30只裸鼠,随机分成三组,所有鼠左侧皮下移植人脂肪细胞,在另一侧10只注射硅凝胶,10仅行皮下穿刺,剩下10只无任何处置,8周取皮肤组织做HE、Masson'染色观察皮肤真皮层厚度及真皮层内胶原蛋白的含量。结果:取材时,所有裸鼠上都能看到所移植的脂肪,但体积较术前有较明显缩小。肉眼看,脂肪呈正常外观,有较多新生血管生成。组织学检测,移植脂肪外周有大量细胞外基质形成,实验侧真皮层较对照侧明显增厚,真皮内胶原含量增多。结论:移植的脂肪组织不仅仅是一种填充物,在改善轮廓的同时,还有真皮增厚、胶原含量增加等皮肤改善的效应。Objective To investigate the histologic modifications of the skin after fat tissue grafting. Methods Thirty nude mice,divided into three groups randomly,were used in the experiment.All 30 mice received human fat tissue on left side.On the opposite side,10 mice received silicone gel,10 mice received only subcutaneous tunneling,and the remaining 10 mice received nothing （negative control group）. Eight weeks later, biopsies of the skin and ubcutaneous tissue were performed and specimens were analyzed by hematoxylin-phloxin-saffron and Masson＂ staining. Dermis thickness was measured. Results Fat tissue was found in all animals. Macroscopically,fat tissue presented normal aspects,with abundant peripheral neovascularization.Histologic examination showed abundant extracellular matrix around the injected human fat tissue. Dermal thickness after fat grafting was significantly greater and collagen also increased significantly. Conclusions This study shows that fat tissue grafting stimulates a neosynthesis of collagen fibers at the recipient site and makes the dermis thicker. The effect it presented at the grafted area was not just volumeincreasing but skin quality improvement.

关 键 词：脂肪注射移植 皮肤质地改善 

分 类 号：R622[医药卫生—整形外科]