顶复门原虫电子转移链代谢及Ⅱ型NADH脱氢酶研究进展  

Research Advances on Electron Transfer Chain and Type Ⅱ NADH Dehydrogenases,NDH-2s in Apicomplexa

作　　者：廖申权[1] 蔡建平[1] 戚南山[1] 吴彩艳[1] 吕敏娜[1] 袁建丰[1] 余劲术[1] 孙铭飞[1] 

机构地区：[1]广东省农业科学院兽医研究所,广州510640

出　　处：《畜牧兽医学报》2012年第1期1-6,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：广东省国际科技合作专项(2008A050200015);广东省自然科学基金项目(1045106001006126);广东省农业科学院院长基金项目(201014;201115);广东省农业科学院兽医研究所所长基金项目(2010)

摘　　要：顶复门原虫是包括刚地弓形虫、疟原虫及球虫等在内的一大类寄生性原虫的总称,可引起重要的人畜寄生虫病。抗顶复门原虫药物的长期使用,甚至是滥用,使得这类寄生虫对现有药物产生了明显的抗药性,急需开发新型药物。Ⅱ型NAD(P)H脱氢酶是电子转移链途径中的关键酶,由于其仅存在于某些植物、细菌、真菌和寄生原虫等一些低等生物体内,而在高等动物体内缺失,是研发新型抗感染性药物的重要靶标。笔者主要针对顶复门原虫线粒体电子转移链代谢途径以及Ⅱ型NAD(P)H脱氢酶的研究概况进行综述。Infections with apicomplexan parasites are major causes of several parasitic diseases in human and animal. Unfortunately, the drug misuse has slowly led to the wide and serious drugs resistance in apicomplexan parasites, rendering serial drugs much less effective. Developing new and effective drugs against parasitic diseases has become extremely urgent. Many apieomplexans have an electron transport chain （ETC） superficially resembling that of the yeast Saccharornyces cerevisiae. The inherent difference between ETC pathways of the parasite and the host make it an appealing target for the development of novel drug. It has recently been demonstrated that an ＂alternative＂ or type 11 NADH dehydrogenases （NDH-2s） involved in ETC is completely lacking in host, NDH-2s were proposed to be promising drug targets against apicomplexa. ETC pathways and NDH-2s of apicomplexan parasites were reviewed.

关 键 词：顶复门原虫 电子转移链 Ⅱ型NAD(P)H脱氢酶 药靶 

分 类 号：S852.723[农业科学—基础兽医学] Q591[农业科学—兽医学]