胰腺实性-假乳头状瘤的临床病理和免疫组化研究  

Solid-pseudopapillary tumor of the pancreas:a clinicopathological and immunohistochemical study

作　　者：普文静[1] 赵静[1] 孙振柱[1] 王盛[1] 张晓军[1] 

机构地区：[1]新疆维吾尔自治区人民医院病理科,乌鲁木齐830001

出　　处：《农垦医学》2011年第4期297-300,共4页Journal of Nongken Medicine

摘　　要：目的:探讨胰腺实性-假乳头状瘤(SPT)的临床病理、组织来源及免疫组化。方法:对6例SPT患者的临床和病理资料进行分析及用以下13种抗体进行免疫组化标记,E-cadherin、β-catenin、α1-AT、CK7、AEl/AE3、Vimentin、Syn、NSE、CD56、PR、CD10、CD117、Ki-67。结果:肿瘤组织由假乳头状区、实性区及囊性区混合组成,假乳头状是肿瘤的主要组织学结构。肿瘤表达AEl/AE3、Vimentin、Syn、NSE、CD56,β-catenin和PR,弱表达α1-AT;部分表达CD10和CD117;不表达E-cadherin。结论:SPT的发生可能与β-catenin异常核表达和E-cad-herin表达缺失有关,免疫组化提示其可能起源于胰腺胚胎的多潜能干细胞,结合多种免疫组化的标记有助于该病的诊断。Objective： To investigate the clinic pathological characteristics and histogenesis of. solid -pseudopapil- lary tumor of the panereas（SPT） . Methods：We analyzed the elinieopathologieal features of 6 SPT. Using immunohistochemical methods , the expression of E - cadhefin, β- eatenin, α1- AT, CK7, AE1/AE3, Vimentin, Syn, NSE, CD56, PR, CDI0,CD117 and Ki -67were observed in 6 eases of SPT. Results：The neoplasms consisted of 3 distinct histolc..：;ic eompo- nents： papillary, cystic, and solid. The majority of SPT showed pseudopapillary tumor pattern. ning revealed the tumor expressed AE1/AE3, Vimentin , Syn, NSE, CD56, β-catenin and PR, weak expressed α1- AT; were negative for E - cadherin staining. Conclusion： he nuclear localization of β-catenin as well as E - cadherin loss are important changes in SPT. Immunohistochemistry is helpful to dignosis.

关 键 词：胰腺实性-假乳头状瘤 临床病理 免疫组化 

分 类 号：R735.9[医药卫生—肿瘤]