Cysc的动态变化对妊高症的早期预防及临床诊疗价值  

Clinical significance of cystatin C measurement in pregnancy induced hypertension

作　　者：孙雪荣[1] 李海峰[1] 于春冬[1] 蒋玉红[1] 魏涛[2] 

机构地区：[1]青岛市妇女儿童医疗保健中心检验科,山东266012 [2]青岛市市立医院,山东266012

出　　处：《中国优生与遗传杂志》2011年第12期66-67,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨妊高症(PIH)患者血清胱抑素C(CysC)的变化及其对诊断PIH患者早期肾损伤的临床意义。方法对轻、中、重PIH患者共67例和正常晚期妊娠孕妇45例分别检测血清CysC,尿素氮(BUN)和肌酐(Crea),并进行分析比较。结果 PIH患者轻、中、重各组与正常晚期妊娠孕妇组比较,血清CysC的浓度明显升高(P<0.05),且随着病情加重,CysC也显著增加。而血BUN,血Crea的浓度与正常对照组比较无明显差异(P>0.05)。结论血清CysC可在肾轻微损伤时升高,较血BUN,血Crea更敏感,安全。对各阶段PIH患者均有较好的早期肾损伤诊断价值。Objective： To investigate the changes and significance of serum cystatin C （CysC） in early renal impairment in patients with pregnancy induced hypertension （PIH）. Methods： The levels of CysC, BUN and Crea were detected in 67 patients with PIH. 45 normal late pregnancy women servered as controls. Results： The serum CysC in PIH patients were higher than those in the controls （P 〈 0.05）, while the serum levels of BUN and Crea had no significant difference between two groups （P 〉 0. 05 ）. Conclusions： The serum CysC determination is a more sensitive and safer parameter in patients with impaired renal function. Early diagnosis of renal impairment can be made by detection of CysC in PIH patients.

关 键 词：妊高症 胱抑素C 肾功能损害 

分 类 号：R714.25[医药卫生—妇产科学]