妊娠10-16周甲状腺功能减退的流行病学研究  

Epidemiological research on hypothyroid of pregnant women in 10-16 weeks gestatioan

作　　者：何耀娟 郭勇 崔咏怡 

机构地区：[1]广州市妇女儿童医疗中心,广州510623

出　　处：《中国优生与遗传杂志》2011年第12期80-82,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过孕期血清检查,统计本地妊娠期临床及亚临床甲状腺功能减退的发病情况,探讨妊娠10-16周进行甲状腺功能检查的筛查意义。方法随机选取来429位我院定期产检的妊娠10-16周的孕妇,进行产科常规检查的同时进行血液甲状腺功能三项的检测:促甲状腺激素(TSH),血清游离三碘甲状腺原氨酸(FT3)与血清游离甲状腺素(FT4)。并进一步追踪其妊娠结局及新生儿结局。结果 429例妊娠10-16周孕妇中临床及亚临床甲状腺功能减退共24例,患病率为5.6%,其中临床甲减为2例,占全部孕妇的0.47%。甲状腺功能亢进20例,患病率为4.7%,20孕周时复查甲状腺功能调整亚甲减患病率为3.72%。早产发生率在甲减及亚甲减组高于正常人群组。结论在妊娠10-16周进行甲状腺功能检查,对及时发现妊娠期甲状腺功能异常有重要意义,可作为该孕期常规产检项目。Objective ： To calculate the prevalence of clinical and subclinical hypothyroid in women of 10 - 16weeks pregnancy by serum test and investigate the importance of thyroid function screening in that gestation. Methods ： 429 women of 10 - 16weeks gestation were selected at random and their serum TSH, FT3 and FT4 with other routine test were checked, their pregnant and neonatal result were also observed. Results： 24 clinical and subclinical hypothyroid patients were observed in 429 pregnant women, the morbidity was 5. 6%, including 0. 47% clinical hypothyroid, meanwhile, 20 hyperthyroid patients were observed, its morbidity was 4. 7%. The premature birth rate was higher in hypothyroid group than in normal group. Conclusions： Thyroid function screening in 10 - 16weeks gestation is of great significance, we believe it can be regarded as a routine test for pregnant women.

关 键 词：妊娠 甲状腺功能减退症 前瞻性 流行病学 

分 类 号：R581.2[医药卫生—内分泌]