三种抗病毒药联合丙种球蛋白治疗小儿传染性单核细胞增多症疗效观察  

Clinical observation on three different antiviral plus gamma globulin for infectious mononucleosis in children

作　　者：王明圣[1] 靳杭红[1] 吴晓庆[1] 孙丽君[1] 

机构地区：[1]成都军区昆明总医院儿科,云南昆明650032

出　　处：《中国优生与遗传杂志》2011年第12期130-131,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨三种不同抗病毒药物联合丙种球蛋白(IVIG)治疗小儿传染性单核细胞增多症的治疗效果。方法将125例生长发育正常且确诊为传染性单核细胞增多症(IM)患儿随机分为A、B、C三组,A组给予更昔洛韦(GCV)﹢IVIG、B组给予α-干扰素(IFN-α)﹢IVIG和C组给予利巴韦林﹢IVIG治疗,对其疗效进行对比分析。结果 A组有效率为97.62%与B(有效率为85.00%)、C组(有效率为74.42%)比较有显著性差异(P<均0.01)。A组住院时间明显短于B、C两组(P<0.05)。结论更昔洛韦﹢丙种球蛋白治疗能明显提高IM患儿的临床效率,缩短病程,改善预后。Objective： To explore The clinical value of three different antivircal plus gammaglobulin for infectious mononucleosis （IM） in children. Methods： 125 pediatric patients with IM were randomy divided into three groups： group A was treated with gancicovir （GCV） cambined with gammaglobulin （IVIG）, group B was treated with IFN - α cambined with IVIG, group C was treated with ribavirin cambined with IVIG. The time of relief of manifestation was analyzed. Results： The total effectual rates of A group A （97.62%） was higher significantly than group B （85.00%） and group C （74. 42% ） （P 〈0. O1 ）, and the hospitalization of group A was shorter significantly than group B and group C （P 〈 O. 05 ）. Cnclusion： GCV plus IVIG can obviously improved the clinical efficacy and prognosis, and the cours of treatmen was obviously shortened.

关 键 词：更昔洛韦 Α-干扰素 利巴韦林 丙种球蛋白 小儿 传染性单细胞增多症 

分 类 号：R725.1[医药卫生—儿科]