职业暴露人群A(H5N1)和甲型H1N1流感血清抗体分析  

Serologic analysis of influenza A(H5N1) and pandemic influenza A(H1N1 2009) among Population with Occupational Exposure in Shandong Province

作　　者：刘倜[1,2,3] 王宇路[1,2,3] 张圣洋[1,2,3] 宋绍霞[1,2,3] 王兰英[1,2,3] 王显军[1,2,3] 

机构地区：[1]山东省疾病预防控制中心病毒性传染病防制所 [2]山东省传染病预防控制重点实验室 [3]山东大学预防医学研究院,济南250014

出　　处：《中国卫生检验杂志》2011年第12期2944-2946,共3页Chinese Journal of Health Laboratory Technology

基　　金：山东省科技厅计划项目(2009GG10002054)

摘　　要：目的:了解人禽流感A(H5N1)和甲型H1N1流感职业暴露人群中的感染状况。方法:对职业暴露人群进行个案调查,采用血凝抑制法(HI)检测职业暴露人群血清中人禽流感A(H5N1)和甲型H1N1流感抗体。结果:2009年-2010年采集的624份职业暴露人群血清中未检测出人禽流感A(H5N1)抗体,而在2009年采集的血清中有5份检测出甲型H1N1流感抗体,抗体阳性率为1.55%,2010年采集的血清中抗体阳性率为11.96%,其中<29岁阳性率为17.19%,30岁～59岁阳性率为10.87%。结论:职业暴露人群中未检测出A(H5N1)流感抗体,但仍需加强职业暴露人群监测。同时甲型H1N1流感抗体水平较低,缺乏相应的抗体水平保护。Objective：To study influenza A（H5N1） and pandemic influenza A（H1N1 2009） infection among population with occupational exposure in Shandong province.Methods： All sera of population with occupational exposure in 2009-2010 were detected with Hemagglutination-inhibition（HI） test to observe the antibody of influenza A（H5N1） and pandemic influenza A（H1N1 2009）.Results： No serum samples collected in 2009-2010 were found to be positive for antibodies against influenza A（H5N1）.Five serum samples collected in 2009 were found to be positive for antibodies against pandemic influenza A（H1N1 2009）,the positive rate was 1.55%;the positive rate in 2010 was 11.96%,17.19% for group under 29 years and 10.87% for group between 30~59 years.Conclusion： No human-avian A（H5N1） infection was found among occupational exposed population in Shandong.Moreover,the surveillance of occupational exposed population must be improved.At the same time,the positive rate of antibody to pandemic influenza A（H1N1 2009） is still low,the effective protection by antibody has not been formed.

关 键 词：人禽流感A(H5N1) 甲型H1N1流感 血清分析职业暴露人群 

分 类 号：R373.13[医药卫生—病原生物学]