温州地区不孕不育患者血清中抗精子抗体与抗心磷脂抗体的关系研究  

Research on relationship of AsAb and ACA in serum of infertility patients in Wenzhou

作　　者：葛海峰[1] 王友沛[2] 庞玲霞[3] 

机构地区：[1]温州医学院附属第二医院育英儿童医院检验科,浙江温州325027 [2]温州医学院附属眼视光医院检验科,浙江温州325027 [3]温州医学院机能实验中心,浙江温州325035

出　　处：《中国卫生检验杂志》2011年第12期2976-2977,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨抗精子抗体(AsAb)、抗心磷脂抗体(ACA)与不孕不育的关系。方法:采用酶联免疫吸附(ELISA)法检测434例男性不育患者血清中的AsAb;892例女性不孕不育患者及40例正常对照组血清中的AsAb及ACA抗体。结果:①1326例不孕不育患者中抗精子总抗体的阳性率为21.4%,高于对照组7.5%,与正常对照组相比差异有统计学意义。其中男性抗精子总抗体的阳性率为23.6%;女性抗精子总抗体的阳性率为20.4%。②ACA的总阳性率为36.6%(643/1756),与正常对照组相比差异有统计学意义。结论:AsAb、ACA检测有助于临床免疫性不孕症的诊断,可为免疫性不孕不育患者诊断及治疗提供实验室依据。Objective：To study the role of antisperm antibody（AsAb） and anticardiolipin antibody（ACA） in patients with infertility.Methods： With ELISA,serum AsAb were tested in 434 infertile male patients,AsAb and ACA in serum were detected in 892 infertile female patients and 40 normal people（control group）.Results： ①The positive rate of AsAb in the serum of infertile patients was much higher than that of normal control group（P0.05）.The positive rates of AsAb in infertile male group and infertile female group were 23.6% and 20.4% respectively.②The positive rate of ACA in infertile patients was much higher than that of normal control group（P0.05）.Conclusion： The evaluation of serum AsAb and ACA is of higher clinical value in the diagnosis of infertility.It can provide laboratory basis for diagnosis and treatment of infertility.

关 键 词：抗精子抗体(AsAb) 抗心磷脂抗体(ACA) 不孕不育 

分 类 号：R711.6[医药卫生—妇产科学]