阿托伐他汀对血脂正常1级或2级老年高血压的影响  

Effects of atorvastatin on mild-to-moderate senile hypertension with normal blood lipid

作　　者：阮力[1] 向群[1] 闻维[1] 

机构地区：[1]怀化市第五人民医院,湖南怀化418000

出　　处：《现代医药卫生》2011年第23期3543-3545,共3页Journal of Modern Medicine & Health

摘　　要：目的:观察阿托伐他汀对血脂正常、1级或2级老年高血压的疗效。方法:本组52例随机分为治疗组27例和对照组25例,对照组给予左旋氨氯地平2.5 mg/次,每日上午1次,治疗组在上述基础上再予阿托伐他汀钙片10 mg/次,每日晚上1次,两组治疗共12周。结果:经治疗后4周、8周、12周,两组SBP、DBP及PP均有所下降(P<0.01)。治疗8周后,SBP、DBP及PP两组间差异均无统计学意义(P>0.05);治疗12周后,SBP、PP两组间差异均有统计学意义(P<0.05),但DBP改善情况两组差异无统计学意义。治疗前后血脂,无论组内或组间比较,差异均无统计学意义(P>0.05)。结论:阿托伐他汀有一定协同降压作用,可促进选择性地降低SBP和缩小PP,有利于血脂正常、轻中度老年高血压的治疗。Objective：To observe the effects of atorvastatin on mild-to-moderate senile hypertension with normal blood lipid.Methods：52 patients were randomly divided into the treatment group（n=27） and the control group（n=25）.The control group was given levamlodipine 2.5mg once every morning for 12 week and the treatment group was given levamlodipine 2.5mg once every morning and atorvastatin calcium10mg once every night for 12 weeks.Results：After 4,8,12 weeks of treatment,SBP,DBP and PP were decreased in the two groups（P0.01）.After 8-week treatment,SBP,DBP and PP had no statistical difference between the two groups（P0.05）.After 12 week treatment,there was statistical difference in SBP and PP between the two groups（P0.05）,but the improvement of DBP had no statistical difference.Before and after treatment,the blood lipid had no statistical significance in comparison between intra-groups or between inter-groups（P0.05）.Conclusion：Atorvastatin has certain synergic antihypertensive effect,selectively decreases SBP and reduces PP,which could be helpful for treating mild-to-moderate senile hypertension with normal blood lipid.

关 键 词：阿托伐他汀 左旋氨氯地平 血脂正常 老年高血压 脉压 

分 类 号：R5[医药卫生—内科学]