雄激素非依赖性前列腺癌发生机制相关的信号传导通路研究进展  

Signaling pathway related to mechanism of androgen-independent prostate cancer

作　　者：蒋先训[1] 王毅[1] 彭潋[1] 

机构地区：[1]南华大学附属第二医院泌尿外科,湖南衡阳421101

出　　处：《现代医药卫生》2011年第23期3584-3585,共2页Journal of Modern Medicine & Health

摘　　要：几乎所有经过内分泌治疗的前列腺癌(prostate cancer,PCa)患者都会发展为雄激素非依赖性前列腺癌(androgen-inde-pendent prostate cancer,AIPC),而目前对AIPC尚无有效的治疗手段,因此,探索AIPC可能的发生机制成为基础与临床研究的重点,本文就与AIPC相关的信号传导通路研究进展做一综述。Almost all patients with endocrine therapy for prostate cancer will progress to androgen-independent prostate cancer（AIPC）.At present,AIPC has no effective treatment.Therefore,exploring the possible mechanism of AIPC becomes the focus of basic and clinical research.This paper reviews the signaling pathway related to the mechanism of AIPC.

关 键 词：雄激素非依赖性前列腺癌 磷脂酰肌醇-3-激酶 雄激素受体 肿瘤干细胞 

分 类 号：R6[医药卫生—外科学]