甲醛遗传毒性及其机制研究进展  

THE RESEARCH FOR GENETOXIC AND MECHANISM OF FORMALDEHYDE

作　　者：陈文婕[1] 戴红[1] 

机构地区：[1]内蒙古医学院公共卫生学院,内蒙古呼和浩特010059

出　　处：《内蒙古医学院学报》2011年第6期519-523,共5页Acta Academiae Medicinae Neimongol

摘　　要：甲醛是易挥发、强氧化性的有机化学物质。大量的动物实验及流行病学研究表明甲醛具有遗传毒性,是具有人类三致效应的重要危险因素;研究还从不同着眼点揭示了甲醛可能的毒作用机制:强氧化剂直接氧化核酸分子;通过抑制SOD酶活力和耗尽细胞内GSH含量导致DNA间接损伤作用;致使细胞分裂期染色体断裂。本文对近年来国内外学者有关甲醛遗传毒性及其机制的研究展开阐述。Formaldehyde is one of organic substances which is volatile and has strong oxidizing property.Large number of animal experiments and epidemiological studies have shown that formaldehyde is genotoxic,is a important risk factor for the human three-induced effect;the study also revealed the possible toxic mechanism of formaldehyde from different focus： a strong oxidant which direct oxidize nucleic acids;lead to indirect DNA damage by inhibiting SOD activity and exhausting intracellular GSH levels;resulting in chromosome breakage in cell division phase,.This paper started elaboration about genotoxic and mechanism of formaldehyde from domestic and foreign scholars in recent years.

关 键 词：甲醛 遗传毒性 机制 

分 类 号：R136.3[医药卫生—劳动卫生]