结核病患者血清中IL-4,IL-6,TGF-β的测定及临床意义  

Clinical significance of serum IL-4,IL-6 and TGF-β in tuberculosis patients

作　　者：聂尚丹[1] 陈廷[2] 刘晓娟 侯春生[4] 石俊仕[5] 赵月霞[6] 李雷生[1] 

机构地区：[1]济宁医学院医学检验学系,山东济宁272000 [2]济宁医学院继续教育学院 [3]山东省莱西市市立医院 [4]济宁市传染病院 [5]济宁市结核病防治所 [6]济宁市第一人民医院

出　　处：《中国预防医学杂志》2011年第12期1011-1013,共3页Chinese Preventive Medicine

基　　金：济宁市科技局资助项目

摘　　要：目的探讨肺结核患者血清中IL-4、IL-6、TGF-β的水平及其临床意义。方法采用酶联免疫吸附试验测定42例肺结核患者及28例健康人群血清细胞因子水平。比较肺结核患者与健康人群、肺结核患者涂阳病例和涂阴病例、初治病例与复治病例间血清IL-4,IL-6,TGF-β水平差异。结果肺结核组血清中IL-4水平较对照组升高,肺结核患者中涂阳病例IL-6水平较涂阴病例升高,TGF-β水平复治病例较初治病例升高,差异均具有统计学意义(P<0.05)。肺结核组IL-6、TGF-β水平与健康对照组比较,肺结核患者中IL-4、TGF-β水平涂阳病例与涂阴病例比较,肺结核患者IL-4、IL-6水平初治病例与复治病例比较,差异均无统计学意义。在肺结核组及健康对照组中,血清IL-6的含量与TGF-β的含量间存在正相关关系。结论 IL-4、IL-6和TGF-β是参与肺结核患者抗感染免疫的重要调节因子,其血清水平可作为监测病情活动和转归的有用指标。Objective To explore the clinical significance of serum IL-4,IL-6 and TGF-β in tuberculosis（TB） patients.Methods We selected 42 TB patients and 28 healthy controls for the study.All participants were tested for serum IL-4,IL-6 and TGF-β levels with ELISA reagents.Results The concentration of IL-4 was significantly higher in TB patients than in controls（P0.05）.The concentration of serum IL-6 was higher in TB smear-positive patients than in TB smear-negative patients（P0.05）.TGF-β increased significantly with the progress of treatment（P0.05）.There was a positive correlation between the levels of IL-4 and TGF-β among participants.Conclusion IL-4,IL-6 and TGF-β might be useful for the prognosis of pulmonary tuberculosis.

关 键 词：结核病 白细胞介素-4 白细胞介素-6 转化生长因子-Β 

分 类 号：R521[医药卫生—内科学] R446.62[医药卫生—临床医学]