An approach to synthesis of(Z)-2-chloro-1,3-diarylpropen-1-ones by Vilsmeier reagent(bis-(trichloromethyl)carbonate/DMF)  

作　　者：Yi Yi Weng Jian Jun Li Wei Ke Su 

机构地区：[1]Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China

出　　处：《Chinese Chemical Letters》2011年第12期1395-1398,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.20806073 and 20876147);the National Key Technology Research and Development Program(No.2007BAI34B06) for financial support

摘　　要：A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.

关 键 词：Ring-opening Halogenation Vilsmeier reagent Bis-（trichloromethyl）carbonate （Z）-2-Chloro-1 3-diaryl-2-enones 

分 类 号：TQ225.52[化学工程—有机化工] TQ612.6