AMI患者胆红素水平与冠脉病变程度的相关性  

Relationship between serum bilirubin and the severity of coronary artery stenosis in patients with acute myocardial infarction.

作　　者：田江华[1] 田梦圆 昃峰[1] 张海澄[1] 刘健[1] 卢明喻[1] 王伟民[1] 刘元生[1] 郭继鸿[1] 

机构地区：[1]北京大学人民医院,100044 [2]河南烟厂总医院,455001

出　　处：《临床心电学杂志》2011年第6期428-431,共4页Journal of Clinical Electrocardiology

摘　　要：目的探讨急性心肌梗死患者血清胆红素水平与冠状动脉病变严重程度的相关性。方法选取经冠状动脉造影确诊为急性心肌梗死的患者291例,测定患者血清总胆红素(TBIL)、总胆固醇(TC)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及甘油三酯(TG)水平。以冠脉病变支数、冠脉狭窄程度及冠脉病变积分来评价冠状动脉病变的严重程度。结果急性心肌梗死单支病变患者血清TBIL明显高于双支病变(p=0.042)和三支病变(p=0.013)患者,血清TBIL水平与冠脉病变支数呈负相关(p=0.039)。而急性心肌梗死双支病变与三支病变相比血清TBIL水平无显著降低(p=0.746)。血清TBIL水平与冠状动脉评分无显著相关性。结论血清胆红素水平在一定程度上可能与急性心肌梗死单支病变相关。Objective We sought to assess the relationship between serum total bilirubin level and the degree of coronary artery stenosis on patients with acute myocardial infarction.Methods A total of 291 patients with acute myocardial infarction who had underwent coronary angiography entered the study.The level of serum TBIL,TC,LDL,HDL and TG were collected.We use the stenosis number of involvement coronary and scores to evaluate the severity of coronary artery.Results Serum TBIL in single-vessel disease is higher than double-vessel disease and three-vessel disease,Serum TBIL level was gradually decreased among the three groups.The analysis of variance for inter-group comparison is significantly different（F=3.269,p=0.039）,but double-vessel disease and three-vessel have no statistics significance（p=0.746）.Analysis of the relationship between three scores and bilirubin,the results show that three scores have no correlation with TBIL.Conclusions Serum TBIL is correlated with the AMI patient with single-vessel disease.

关 键 词：血清总胆红素 血脂 冠状动脉造影 急性心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]