老年重症肺炎抗生素降阶梯治疗及比阿培南的应用  

Antibiotic De-escalation Therapy vs.Biapenem for Elderly Patients with Severe Pneumonia

作　　者：闫翔[1] 范慧民[1] 李钰[1] 沈桂林[1] 陈曦[1] 

机构地区：[1]解放军成都军区总医院老年病科,成都610083

出　　处：《中国医院用药评价与分析》2011年第12期1126-1128,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:评价降阶梯治疗策略治疗老年重症肺炎的疗效。方法:回顾分析2008年1月—2011年1月解放军成都军区总医院老年科重症肺炎患者42例,分为治疗组(降阶梯治疗组,21例)和对照组(传统治疗组,21例),比较2组的不适当抗生素治疗发生率、临床疗效、细菌清除率、感染控制天数、住院费用等指标。结果:治疗组与对照组比较总有效率分别为90.48%(19/21)、61.90%(13/21);细菌清除率分别为82.60%(19/23)、59.09%(13/22);感染控制天数分别为(8.5±4.8)、(13.3±6.4)d,2组比较差异显著,有统计学意义(P<0.05);不适当抗生素治疗发生率和住院费用明显低于对照组,差异显著,有统计学意义(P<0.01)。结论:抗生素降阶梯疗法能迅速控制感染,提高治愈率,对老年重症肺炎可获得良好疗效。OBJECTIVE： To evaluate the efficacy of antibiotic de-escalation therapy for elder patients with severe pneumonia.METHODS： A total of 42 old patients with severe pneumonia hospitalized in PLA General Hospital of Chengdu Military Command from Jan.2008 to Jan.2011 were assigned to receive either antibiotic de-escalation therapy（treatment group,n=21） or traditional therapy（control group,n=21）,with the incidence of improper antibiotic treatment,clinical efficacy,bacterial clearance rate,days of infection control and hospitalization costs etc analyzed retrospectively.RESULTS： In the treatment group vs.control group,the total effective rate was 990.48%（19/21） vs.61.90%（13/21）,with bacterial clearance rate of 82.60%（19/23） vs.59.09%（13/22）,infection control of（8.5±4.8） days vs.（13.3±6.4） days,all showing significant differences（P0.05）.There were significant differences in incidence of improper antibiotic treatment and hospitalization costs between the two groups（P0.01）.CONCLUSION： Antibiotic de-escalation therapy is of remarkable efficacy for severe pneumonia in elderly patients for it can rapidly keep the infection under control and increase the cure rate.

关 键 词：老年人 重症肺炎 降阶梯治疗 比阿培南 

分 类 号：R978.1[医药卫生—药品]