盐敏感性高血压患者胰岛素抵抗性及其与炎症因子的关系  

The relationship between insulin resistance and inflammatory factors in salt sensitive hypertension patients

作　　者：高峰[1] 刘哲[1] 周静[1] 万招飞[1] 高智耀[1] 白怀生[1] 刘兆英[1] 

机构地区：[1]延安大学附属医院心血管内科一病区,陕西延安716000

出　　处：《延安大学学报（医学科学版）》2011年第4期12-14,共3页Journal of Yan'an University:Medical Science Edition

摘　　要：目的探讨盐敏感性高血压患者胰岛素抵抗状况及其与炎症因子的关系。方法对190例高血压患者采用急性盐水负荷试验,确定盐敏感性高血压125例,非盐敏感性高血压65例,分别进行糖耐量试验及胰岛素同步释放试验,对炎症因子指标HsCRP,IL-6进行检测。结果与盐不敏感性高血压患者相比,盐敏感性高血压患者空腹血糖水平与血胰岛素水平显著增高,胰岛素敏感指数降低;高糖负荷后血糖水平与血胰岛素水平显著增高,胰岛素敏感指数显著降低;盐敏感性高血压患者炎症因子HsCRP,IL-6水平较非盐敏感性高血压患者明显升高,差异有统计学意义。结论盐敏感性高血压患者存在更严重的胰岛素抵抗,且其非特异性炎症因子水平高于盐不敏感者。Objective To explore the relationship between insulin resistance and inflammatory factors in salt sensitive high blood pressure patients.Method：190 cases of patients,salt sensitivity high blood pressure in 125 cases,the salt sensitivity high blood pressure in 65 cases,performed glucose tolerance test,insulin release test,and inflammation,synchronous factor,IL-6 HsCRP inspection.Results：Salt sensitivity patients with high blood pressure had raised fasting blood sugar level,decreased insulin sensitivity index,significantly high sugar level after blood glucose load,and significantly lower insulin sensitivity index.Conclusion：Salt sensitivity of hypertension patients have more severe insulin resistance,and their nonspecific inflammation factors level is higher than the salt insensitive patients.

关 键 词：高血压 盐敏感性 胰岛素抵抗 炎症因子 

分 类 号：R544.1[医药卫生—心血管疾病]