不同糖耐量状态孕妇血清1,5-脱水葡萄糖醇的研究  

Serum 1,5-anhydroglucitol in pregnant women with different glucose tolerance status

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作  者:陈家坚[1] 温卓莲[1] 梁亮[1] 

机构地区:[1]广西壮族自治区北海市人民医院检验科,536000

出  处:《中国医师进修杂志》2011年第36期6-8,共3页Chinese Journal of Postgraduates of Medicine

摘  要:目的通过测定不同糖耐量状态孕妇血清1,5-脱水葡萄糖醇(1,5-AG),探讨其在妊娠期糖尿病(GDM)诊断中的价值。方法测定30例GDM孕妇(GDM组)、32例妊娠期糖耐量受损孕妇(GIGT组)及43例妊娠期糖耐量正常孕妇(GNGT组)的血清1,5-AG、空腹血糖(FPG)、1h血糖(1hPG)、糖化血红蛋白(HbA1C)。结果GDM组血清1,5-AG水平[(11.69±3.92)mg/L]显著低于GIGT组[(20.93±3.43)mg/L]和GNGT组[(27.83±4.03)mg/L](P〈0.01),GIGT组低于GNGT组(P〈0.05)。孕妇血清1,5-AG与FPG、1hPG、HbA.c均呈显著负相关(P〈0.01)。结论孕妇血清1,5-AG与糖耐量下降相关,1,5-AG可作为GDM的诊断指标。Objective To explore the diagnosing value of serum 1,5-anhydroglucitol(1,5-AG) for gestational diabetes mellitus (GDM) by determining 1,5-AG in pregnant women with different glucose tolerance status. Methods The levels of serum 1,5-AG,fasting plasma glucose (FPG), 1 hour plasma glucose ( 1 hPG ) and glycosylated hemoglobin ( HbA1c ) were determined in 30 cases GDM (GDM group ), 32 cases gestational impair glucose tolerance (GIGT group) and 43 cases gestational normal glucose tolerance ( GNGT group). Results The level of serum 1,5-AG in GDM group [ ( 11.69 ± 3.92 ) mg/L ] was obviously lower than that in GIGT group [ (20.93± 3.43 ) mg/L ] and GNGT group [ (27.83 ± 4.03 ) mg/L] (P 〈 0.01 ), GIGT group was obviously lower than that in GNGT group (P 〈 0.05). The level of serum 1,5-AG had significantly negative correlation with FPG, 1 hPG and HbA1c respectively(P 〈 0.01 ). Conclusion The level of serum 1,5-AG has significantly correlation with glucose tolerance, 1,5-AG can be used as useful indicator in the diagnosis of GDM.

关 键 词:孕妇 糖尿病 妊娠 1 5-脱水葡萄糖醇 

分 类 号:R714.256[医药卫生—妇产科学]

 

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