角蛋白17、19在银屑病皮损中的表达及意义  

Expression and significance of keratin 17 and 19 in psoriatic lesion

作　　者：郝小军[1] 高顺强[2] 李真[1] 邢文晓[1] 李文素[1] 

机构地区：[1]石家庄市中心医院皮肤科,050011 [2]河北医科大学第四医院皮肤科,石家庄050000

出　　处：《中国医师进修杂志》2011年第36期20-22,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的通过研究角蛋白17、19在银屑病皮损中表达水平的变化，探讨角蛋白17、19在银屑病病理改变中的意义。方法用免疫组织化学方法检测30例银屑病皮损和10例正常皮肤中角蛋白17、19的表达情况。结果银屑病皮损中基底层和棘细胞层角蛋白17的表达水平增强，基底层角蛋白19的表达水平减弱，与正常皮肤比较差异有统计学意义（P〈0．05）。银屑病皮损中角蛋白17表达的吸光度值高于正常皮肤（5．81±1．42比0，P〈0．01）；角蛋白19表达的吸光度值低于正常皮肤（0．49±0．03比2．03±1．08，P〈0．05）；在银屑病皮损中角蛋白17的吸光度值与角蛋白19的吸光度值呈负相关（r=-0．479，P〈0．01）。结论银屑病皮损中角蛋白17、19的异常表达与角质形成细胞在分化过程中存在异常角化有关。Objective To study expression and significance of keratin 17 and 19 in psoriatic lesion. Method The expression of keratin 17 and 19 in 30 psoriatic lesion and 10 normal skin was measured by immunohistochemistry method. Results The expression level of keratinl7 in the psoriatic lesion was higher than that in the normal skin, the expression level of keratin 19 in the psoriatic lesion was lower than that in the normal skin,there were significant differences in the expression of keratin 17 and 19 between them （P 〈 0.05）. The optical density level of keratin 17 in the psoriatic lesion was obviously raised compared with the normal skin （5.81 ± 1.42 vs. 0, P 〈 0.01 ）. The optical density level of keratin 19 in the psoriatic lesion was obviously decreased compared with the normal skin （0.49±0.03 vs. 2.03 ± 1.08, P 〈 0.05）. The optical density level of keratin 17 and 19 showed negative correlation in the psoriatic lesion （r = -0.479, P 〈 0.01 ）. Conclusion Keratin 17 and 19 may play a role in the pathogenesis of psoriasis.

关 键 词：银屑病 免疫组织化学 角蛋白17 角蛋白19 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]