一把双刃剑:胰岛素样生长因子-Ⅰ的双向作用  

A Double Blade Sword:The Bidirectional Effects of Insulin-like Growth Factor-Ⅰ

作　　者：王丽君[1] 谷瑞民[1] 

机构地区：[1]哈尔滨医科大学药学院,黑龙江哈尔滨150081

出　　处：《医学与哲学（B）》2011年第12期66-68,共3页Medicine & Philosophy(B)

基　　金：黑龙江省研究生创新科研项目;项目编号:YJSCX2011-331HLJ;国家自然科学基金项目;项目编号:31171110

摘　　要：胰岛素样生长因子-Ⅰ(insulin-like growth factor-Ⅰ,IGF-Ⅰ)作为一种有丝分裂原,一方面可以促进生长、减少胰岛素抵抗、治疗生长激素不敏感综合征、心衰及肾衰等;另一方面,高水平的IGF-Ⅰ却又与前列腺癌、乳腺癌及结肠直肠癌等相关。同一种活性物质却具有差异如此大的作用,本文将综述并从哲学的思维和视角认识IGF-Ⅰ的双向作用。Insulin--like growth factor--I （IGF--I）, as a mitogen, on one hand exerts positive effects such as promoting the growth of body, decreasing insulin resistance, being used in the treatment of growth hormone insensitivity syndrome, heart failure and renal failure and so on, on the other hand, high plasma IGF--I level is related to prostate, breast and colorectal cancers and so on. One live matter has such distinct effects on the body, and this paper is going to review and understand the bidirectional effects of IGF--I through philosophical thoughts and view.

关 键 词：胰岛素样生长因子-I 癌症 双向作用 

分 类 号：R977.15[医药卫生—药品]