麝香与冰片不同配比对急性脑缺血模型小鼠血脑屏障通透性的影响  

Effect of Moschus and Borneo Camphor in Different Proportion on Blood-brain Barrier Permeability of Acute Cerebral Ischemic Model Mice

作　　者：姚洪武[1] 王建[1] 刘岩[1] 王丹丹[1] 

机构地区：[1]成都中医药大学,四川成都610075

出　　处：《成都中医药大学学报》2011年第4期62-64,80,共4页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划项目(No.2007CB512606)

摘　　要：目的:考察麝香与冰片配伍对急性脑缺血模型小鼠血脑屏障通透性的影响。方法:采用双侧颈总动脉结扎法制造急性脑缺血模型,通过测定渗出脑血管外的伊文思蓝含量分析药物对血脑屏障通透性的影响。结果:假手术组与吐温对照组脑组织伊文思蓝含量无显著差异(P>0.05);模型组与假手术组及吐温对照组比较,伊文思蓝含量明显升高(P<0.05);与模型组比较,各给药组脑组织中伊文思蓝含量均有所降低,其中,麝香与冰片1∶2、1∶3配伍组的伊文思蓝含量显著降低(P<0.05)。结论:麝香与冰片配伍可降低小鼠缺血状态下血脑屏障的通透性,提示二者配伍能调节病理状态下的血脑屏障而起到保护作用。[Objective：] To investigate the effect of moschus and borneo camphor in different proportion on blood-brain barrier（BBB） per-meability of acute cerebral ischemic model mice.Methods： The ligation of both arteria carotis communis was applied to cultivate the model of acute cerebral ischemia,and the effect of medicinals on BBB was analyzed by metering the content of Evan＇s Blue（EB） dis-char ged from the cerebral vessels.Results： There was no significant difference about the EB content in cerebral tissues between the sham operation group and the tween control group（P 0.05）;the EB content of the model group was obviously superior to that of the sham operation group and the tween control group（P 0.05）;compared with the model group,the EB content in cerebral tissues of all the other medication and ministration groups was lower,among which the groups of compatibility of moschus with borneo camphor in propotion of 1∶ 2 and 1∶ 3 got lower notably（P 0.05）.Conclusion： The compatibility of moschus with borneo camphor can decrease the BBB permeability of cerebral ischemic mice,which indicates that the compatibility can regulate the BBB under a patholo gical state to work as protection.

关 键 词：麝香 冰片 配伍 急性脑缺血 血脑屏障 

分 类 号：R289[医药卫生—方剂学] R285.5[医药卫生—中药学]