Analysis of mechanical response of fistula plug for structure optimization  

作　　者：Shunli Yang Bin Jiang Feng Xu Min Lin Guiping Zhao Tianjian Lu 

机构地区：[1]Biomedical Engineering and Biomechanics Center,Xi'an Jiaotong University,Xi'an 710049,China [2]NanJing Hospital of T.C.M,Nanjing 210001,China [3]The Key Laboratory of Biomedical Information Engineering of Ministry of Education,School of Life Science and Technology,Xi'an Jiaotong University,Xi'an 710049,China

出　　处：《Theoretical & Applied Mechanics Letters》2012年第1期36-39,共4页力学快报（英文版）

基　　金：supported by the Major International (Regional) Joint Research Program of China (11120101002);the National Natural Science Foundation of China(10825210 and 31050110125);the National 111 Project of China(B06024)

摘　　要：Anal fistula is one of the three greatest anorectal diseases with a high prevalence. The traditional treatments（e.g., surgery） for fistula have limitations due to damage to the internal anal sphincter of patients. With recent advances in biomaterials, treatments based on biomaterial filling （e.g., scleraprotein injection, fistula plug） have emerged as novel therapies for fistula. The anal fistula plug （e.g., based on small intestinal submucosa （SIS）） has attracted increasing attention because of short term healing rate and biocompatibility. However, challenges remain for this method such as plug falling as observed in clinics. To address this, this paper analyzes the case of SIS falling under physiological condition from mechanical point of view using ANSYS simulation. It then proposes three new geometrical structures for fistula plug and compares their mechanical behavior （e.g., axial stress, reaction of constraint） with that of clinically used structure （cone shape）. Based on the simulation, it optimizes the geometric parameters of fistula plug. The approach developed here can help to improve the design of fistula plug for better clinical treatments.Anal fistula is one of the three greatest anorectal diseases with a high prevalence. The traditional treatments（e.g., surgery） for fistula have limitations due to damage to the internal anal sphincter of patients. With recent advances in biomaterials, treatments based on biomaterial filling （e.g., scleraprotein injection, fistula plug） have emerged as novel therapies for fistula. The anal fistula plug （e.g., based on small intestinal submucosa （SIS）） has attracted increasing attention because of short term healing rate and biocompatibility. However, challenges remain for this method such as plug falling as observed in clinics. To address this, this paper analyzes the case of SIS falling under physiological condition from mechanical point of view using ANSYS simulation. It then proposes three new geometrical structures for fistula plug and compares their mechanical behavior （e.g., axial stress, reaction of constraint） with that of clinically used structure （cone shape）. Based on the simulation, it optimizes the geometric parameters of fistula plug. The approach developed here can help to improve the design of fistula plug for better clinical treatments.

关 键 词：anal fistula small intestinal submucosa fistula plug structure optimization numerical simulation 

分 类 号：S858.292[农业科学—临床兽医学] U416.217[农业科学—兽医学]