自拟方剂联合小剂量西药预防小儿支气管哮喘发作的临床研究  

Clinical study on the effect of self-drafted prescription combined with low-dose of Western medicine on prevention of onset of bronchial asthma in children

作　　者：李琼[1] 王艳[1] 荣潇[1] 焦树平[1] 王淑华[1] 张戬[2] 

机构地区：[1]河北省衡水市哈励逊国际和平医院儿科,053000 [2]河北省衡水市哈励逊国际和平医院中医科,053000

出　　处：《中国妇幼保健》2012年第4期612-614,共3页Maternal and Child Health Care of China

摘　　要：目的:观察自拟方剂与小剂量西药联用预防小儿支气管哮喘发作的临床疗效。方法:选择该院自2010年1月～2011年10月收治的140例小儿支气管哮喘患儿,按照患儿家长自愿原则,随机分为实验组与对照组。实验组70例,口服哮喘清合剂加用小剂量西药;对照组70例,吸入糖皮质激素和(或)孟鲁斯特钠咀嚼片,观察3个月为1个疗程。同时在发作期、缓解期及1个疗程结束后分别做嗜酸粒细胞计数、FENO、肺功能水平。结果:治疗组的总有效率为91.43%(64/70),高于对照组总有效率70.00%(49/70),具有统计学意义(P<0.05);治疗组在肺功能、嗜酸粒细胞计数、FENO指标比较,有统计学差异(P<0.05)。结论:中西医结合疗法防治小儿支气管哮喘,其疗效显著,能明显改善患者的临床症状,提高治愈率,同时安全性高,值得进一步推广应用。Objective： To observe the clinical efficacy of self - dr＇aited prescription combined with low - dose of Western medicine in prevention of onset of bronchial asthma in children. Methods ： A total of 140 children with bronchial asthma who were treated in the hospital from January 2010 to October 2011 were selected, then they were randomly divided into treatment group and control group according to the principle of voluntariness. Seventy children in treatment group were treated with oral administration of asthma clear mixture combined with low - dose of Western medicine; while seventy children in control group were treated with inhalation therapy with glucocorticoid and/or oral administration of chewable tablets of montelukast. Three months were designed as one course. Eosinophil count, exhaled nitric oxide （ FE- NO） , and pulmonary function detection were conducted during attack stage, recovery stage, and after one course. Results： The total effectire rate in treatment group was 91.43% （64/70） , which was significantly higher than that in control group [70. 00% （49/570） ] （P 〈 0.05）; there was significant difference in puhnonary function, cosinophil count, and FENO between the two groups （P〈O. 05） . Conclusion：The clinical efficacy of combination of Chinese traditional medicine and Western medicine is dominant in prevention and treatment of bronchial asthma in children, which can improve the clinical symptoms of the children and increase curative rate, the safety is good, and it is worthy to be further popularized.

关 键 词：哮喘清合剂 小儿支气管哮喘 呼出气一氧化氮 肺功能 嗜酸粒细胞计数 作用机理 

分 类 号：R725.6[医药卫生—儿科]