支气管激发试验在夜间发作性喘息病因诊断中的应用  

Application of bronchial provocation test in etiological diagnosis of night gasping

作　　者：陈众博[1] 虞亦鸣[1] 曹超[1] 丁群力[1] 吕丹[1] 马红映[1] 孙士芳[1] 舒丽华[1] 邓在春[1] 

机构地区：[1]宁波大学医学院附属医院呼吸内科,浙江宁波315020

出　　处：《中国现代医生》2012年第2期43-44,共2页China Modern Doctor

基　　金：浙江省宁波市社会科学发展基金(2010C50012)

摘　　要：目的探讨夜间发作性喘息患者支气管激发试验前后第1秒用力呼气量(FEV1)、呼气中期流速(FEF50)的反应状况。方法 84例夜间发作性喘息患者进行乙酰甲胆碱支气管激发试验,观察FEV1、FEF50的变化。结果支气管激发试验阳性率33%,阳性组患者激发前FEV1(2.88±0.62),激发后FEV1(2.18±0.47),两者之间比较差异具有统计学意义(P<0.01),59例患者呼气中期流速(FEF50)在激发后下降>20%。激发试验后FEF50下降与FEV1下降呈明显正相关性。结论夜间发作性喘息患者的病因常为支气管哮喘,而患者肺功能在白天可以恢复正常,观察患者激发前后FEV1变化,有利于对哮喘的正确诊断。Objective To investigate the changes of FEV1 and FEF50 in night gasping patients before and after bronchial provocation test （BPT）. Methods All of 84 night gasping patients were enrolled to conduct lung function test and BPT. Results Airway hyperresponsiveness was found in 33% subjects based on BPT. There was significant statistical differences between patients with＇airway hyperresponsiveness and without airway hyperresponsiveness in the FEV1 and FEF50 at baseline. In positive group, Pre-BPT testing FEVl （2.88±0.62）, post BlYF testing FEV1 （2.18±0.47）, P〈0.01 ;Post of BPT testing, 20% fall in FEF50 was found in 59 patients. Post BPT changes in FEF50 （FEF50%） were correlated positively to the changes in FEV1 （FEVI%）. Conclusion Usually, night gasping etiology is the cause of asthma, and lung function in those patients daytime maybe normal. Our findings support the possible role of BPT in the diagnosis of asthma among patients with night gasping.

关 键 词：夜间发作性喘息 支气管哮喘 支气管激发试验 

分 类 号：R562.25[医药卫生—呼吸系统]