重组人干扰素α-1b辅治小儿轮状病毒性腹泻疗效观察  

The efficacy observation of recombinant human interferon α-1b in children with rotavirus diarrhea

作　　者：文德年 兰宏平 代秀琼 

机构地区：[1]四川省中江县人民医院儿科,618100

出　　处：《临床合理用药杂志》2012年第4期48-49,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨重组人干扰素α-1b辅治小儿轮状病毒性腹泻的疗效。方法将90例轮状病毒性腹泻患儿随机分为和观察组和对照组各45例。对照组采用常规治疗,观察组在对照组治疗基础上加用重组人干扰素α-1b进行治疗。治疗后比较2组患儿的临床疗效、症状体征改善时间和治疗后3d白细胞、中性粒细胞杆状核、中性粒细胞分叶核水平及不良反应。结果观察组总有效率为95.56%高于对照组的77.78%,症状体征改善时间短于对照组,治疗后3d白细胞、中性粒细胞杆状核及分叶核水平均低于对照组,不良反应发生率为6.67%低于对照组的13.33%,差异均有统计学意义(P<0.05)。结论重组人干扰素α-1b辅治小儿轮状病毒性腹泻的疗效较好,且显效快。Objective To evaluate the efficacy of recombinant human interferon α-1b in children with rotavirus diarrhea.Methods 90 cases children with rotavirus diarrhea were randomly divided into observation group and control group,each of 45 cases.Control group were taken conventional treatment,and observation group were taken recombinant human interferon α-1b treatment on the base of control group.After treatment,compared the clinical effect,the improved time of symptoms and signs,blood cell after treatment 3d,rod-shaped nuclear neutrophils,nuclear lobulation and adverse reaction of two groups.Results The total effective rate of observation group（95.56%） was higher than that of control group（77.78%）,the improved time of symptoms and signs was shorter than that of control group;After treatment 3d,the count of blood cell,rod-shaped nuclear neutrophils and nuclear lobulation were lower than those of control group.The incidence of adverse reaction of observation group（6.67%） was lower than that of control group（13.33%）,there were significantly different（P0.05）.Conclusion It is good effect for recombinant human interferon α-1b in children with rotavirus diarrhea,and it markedly faster.

关 键 词：重组人干扰素Α-1B 腹泻 轮状病毒性 小儿 

分 类 号：R725.1[医药卫生—儿科]