急性心肌梗死患者血清视黄醇结合蛋白4和脂联素水平的变化  

Serum retinol binding protein-4 and adiponectin in acute myocardial infarction

作　　者：邱丽君[1] 丁玉静[1] 崔亚斌[1] 苏卫东[1] 陈春红[1] 

机构地区：[1]天津市第四中心医院检验科,300140

出　　处：《广东医学》2012年第1期72-74,共3页Guangdong Medical Journal

摘　　要：目的测定急性心肌梗死患者视黄醇结合蛋白4(RBP4)和脂联素(APN)血清水平并分析它们的相互关系和影响因素。方法选取急性心肌梗死患者57例(心梗组),正常对照55例(对照组),空腹抽取静脉血液检测血糖、血脂(TC、TG、LDL-C、HDL-C)等,采用酶联免疫吸附法检测血清RBP4和APN水平。结果心梗组较对照组RBP4水平显著升高,APN水平显著降低(P<0.05),两者呈负相关。多元逐步回归分析发现APN、DBP、高血压史及TG为血清RBP4水平的独立相关因素,RBP4、高血压史、HDL-C及DBP为血清APN水平的独立相关因素。结论急性心肌梗死患者血清RBP4水平显著升高,APN水平显著降低。RBP4和APN的变化与急性心肌梗死的发生密切相关。Objective To evaluate the serum retinol binding protein-4（RBP4） an adiponectin（APN） levels in acute myocardial infarction. Methods By enzyme linked immunosorbent assay（ELISA） methods,the fasting levels of serum RBP4 and APN were measured in 57 patients with AMI and 55 healthy controls.The fasting plasma glucose（FPG）,total cholesterol（TC）,triglyceride（TG）,LDL-C and HDL-C were measured simultaneously.SSPS 13.0 was used for statistical analysis. Results The serum RBP4 were significantly higher in AMI patients than that in healthy controls（P0.05）,while the serum APN were significantly lower in AMI patients than that in healthy controls（P0.05）.The serum RBP4 and APN were negatively correlated.According to multiple stepwise regression analysis,APN,diastolic blood pressure,hypertention and TG were independent correlated factors of RBP4.RBP4,hypertention,HDL-C and diastolic blood pressure were independent correlated factors of APN. Conclusion Serum RBP4 increase and APN reduction are significantly observed in patients AMI,suggesting RBP4 and APN play important roles in the pathogenesis AMI.

关 键 词：视黄醇结合蛋白4 脂联素 急性心肌梗死 酶联免疫吸附 

分 类 号：R459.3[医药卫生—治疗学]