大鼠单侧隔核内微量注入TRH或吗啡对痛阈及电针镇痛的影响  

THE EFFECTS OF MICROINJECTION OF TRH OR MORPHINE INTO UNILATERAL NUCLEUS SEPTUM ON PAIN THRESHOLD AND ELECTROACUPUNCTURE ANALGESIA IN RATS

作　　者：涂宗苹[1] 张自东[1] 朱梓香[1] 

机构地区：[1]同济医科大学基础医学部生理教研室

出　　处：《针刺研究》1990年第1期6-12,共7页Acupuncture Research

基　　金：国家自然科学基金资助

摘　　要：我组曾报道脑室注入促甲状腺素释放激素(TRH)能对抗电针镇痛,其作用机理不清。隔核与脑室紧密相邻又是前脑边缘系统的重要结构,与其他边缘系统和脑区都有着密切的联系,它具有多种生理功能。Experiments were performed on awake rats. The pain threshold (tail flick latency. TFL) was measured with radiant heat tail-flick methed. Microinjection of thyrotropin releasing hormone (TRH 2.5μg/1μl) into septal area can increase remarkably and last 40min, but the analgesic effect can not be reversed by the opioid receptor brocker Naloxone (NAL) into the septal area; injection 10μg of Morphine into unilateral septal nucleus, the pain threshold had no obvious change;

关 键 词：隔核 TRH 吗啡 电针 止痛 痛阈 

分 类 号：R245.97[医药卫生—针灸推拿学]