血栓调节蛋白和胎盘蛋白13与子痫前期的相关性分析  

The correlation between the occurrence of pre-eclampsia and thrombomodulin & placental protein 13

作　　者：程彦君[1,2] 凌少云[1,2] 吴雪琴[1,2] 

机构地区：[1]深圳市龙岗中心医院 [2]深圳市第九人民医院妇产科,广东深圳518116

出　　处：《海南医学院学报》2012年第2期232-234,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(11221018)~~

摘　　要：目的:探讨子痫前期患者血栓调节蛋白(TM)和胎盘蛋白13(PP13)水平变化与子痫前期的相关性。方法:选择子痫前期患者64例作为研究对象,根据患者疾病程度分为轻度子痫前期组28例,重度子痫前期组36例。随机选择我院正常妊娠妇女30例作为对照组。应用酶联免疫吸附试验(ELISA)测定3组患者外周血血清TM与PP13水平。结果:(1)轻度子痫前期组、重度子痫前期组妇女血清中TM、PP13水平显著高于对照组妇女(P<0.05)。(2)重度子痫前期组妇女血清中TM、PP13水平显著高于轻度子痫前期组妇女(P<0.05)。结论:子痫前期患者血清中TM、PP13水平异常表达,并随患者病情的严重程度而升高,说明血栓调节蛋白和胎盘蛋白13可能参与子痫前期的发生与发展。Objective： To investigate correlation between the occurrence of pre-eclampsia and thrombomodulin（TM） placental protein 13（PP13）.Methods： A total of 64 patients with pre-eclampsia were included and divided into mild group（28 cases） and severe group（36 cases）.Thirty healthy pregnant women were also recruited as control group.Serum TM and PP13 levels were detected and compared among the three groups using Enzyme-linked immunosorbent assay（ELISA）.Results： ① Serum TM and PP13 levels were significantly higher in the mild and severe group than that in the control group（P0.05）.②Serum TM and PP13 levels were significantly higher in the mild group than that in the severe group（P0.05）.Conclusions： Expression of serum TM and PP13 was abnormal in patients with preeclampsia,showing a worsening trend with sereverity of the disease,which indicate TM and PP13 may play a role in the occurrence and progress of preeclampsia.

关 键 词：子痫前期 血栓调节蛋白 胎盘蛋白13 

分 类 号：R714.24[医药卫生—妇产科学]