酮咯酸氨丁三醇与氟比洛芬酯用于骨科膝关节周围手术术后镇痛对比观察  

Analgesia efficacy comparison of ketorolac tromthamine and flurbiprofen injection for postoperative pain relief after knee operation

作　　者：杨程[1] 闫诺[1] 李娟[1] 王森[1] 

机构地区：[1]武警医学院附属医院麻醉科,天津300162

出　　处：《海南医学院学报》2012年第2期260-262,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(11221026)~~

摘　　要：目的:对比观察氟比洛芬酯与酮咯酸氨丁三醇用于骨科膝关节周围手术术后镇痛(PCA)的效果。方法:选择膝关节周围下肢手术120例,随机分为两组,各60例。氟比洛芬酯(F)组:氟比洛芬酯250mg,酮咯酸氨丁三醇(T)组:酮咯酸氨丁三醇150mg,两组均用生理盐水稀释到100mL,手术结束前半小时接静脉自控镇痛泵。观察记录时点为术后1、4、8、12、24、48h的静态和动态VAS评分、PCA按压次数、镇痛满意度及不良反应。结果:两组患者术后各时点的静态VAS评分及按压次数比较差异无统计学意义(P>0.05),静态VAS评分均<4分。F组术后8、12、24h的动态VAS评分明显高于T组(P<0.05),恶心、呕吐总发生率高于T组(P<0.05)。结论:与氟比洛芬酯相比,酮咯酸氨丁三醇用于膝关节周围手术术后镇痛效果满意,且不良反应少,是术后镇痛的良好选择。Objective： To compare the analgesia efficacy of ketorolac tromthamine and flurbiprofen injection for postoperative pain relief after knee operation.Methods：A total of 120 patients undergoing selective knee operation were randomly divided into two groups with 60 cases in each：The group F was given flurbiprofen injection（250 mg） together with saline 75 mL;while group K was treatment with ketorolac tromthamine（150 mg） together with saline 95 mL.Injections were diluted to be 100 mL for both groups.Self-controlled analgesic pump was provided half an hour before the surgery ended.VAS score within 48 hours（1h,4h,8h,12h,24h,48h） after the operation,and PCA pressing times as well as satisfactory about analgesia effects were recorded between the two groups.Results：The VAS score of rest pain and satisfaction scale showed no significant difference between the two groups.The VAS score of dynamic pain were less in group K than that in the group K（P0.05） at 8h,12h,24h.The incidence of nausea and vomiting were less in group K than that in Group F（P0.05）.Conclusions： Ketorolac tromthamine shows satisfactory analgesia effects for patients undergoing knee operation with less side effects comparing with flurbiprofen injection.

关 键 词：酮咯酸氨丁三醇 氟比洛芬酯 镇痛 动态VAS评分 

分 类 号：R614[医药卫生—麻醉学]