脑啡肽酶抑制剂Acetorphan及SCH34826能够加强大鼠低频电针镇痛  

ENKEPHELINASE INHIBITORS ACETORPHAN AND SCH34826 POTENTIATE THE ANALGESIC EFFECT OF LOW FREQUENCY ELECTROACUPUNCTURE IN RATS

作　　者：周岩[1] 罗非[1] 韩济生[1] 

机构地区：[1]北京医科大学神经科学研究中心

出　　处：《针刺研究》1990年第4期310-314,共5页Acupuncture Research

摘　　要：大量资料提示,电针刺激可在中枢神经系统中释放阿片肽而发挥镇痛作用。近年来又发现,不同频率的电针刺激可激活大鼠中枢神经系统不同种类的阿片肽:低频(2Hz)电针促进脑啡肽释放,高频(100Hz)电针促进脊髓中强啡肽的释放。值得注意的是:有一部分大鼠电针不能引起镇痛效果,称为“电针无效鼠”。Influence of two novel enkephelinase inhibitors, Acetorphan and SCH34826, on the effect of electroacupuncture analgesia (EAA) has been observed in rats. Administered Acetorphan (2.0-4.0mg/kg, i.p.) or SCH34826 (30-100 mg/kg, p.o.) potentiated and prolonged the effect of 2 Hz EAA significantly in the nonresponder in which an evident analgesic effect can not be induced by 2 Hz electroacupuncture. This means that che non-responder of 2 Hz EAA can be converted into the responder with these two drugs. The non-responder of 100 Hz EAA, however, can not be changed into the responder with Acetorphan. These results again support our previous reports that enkephelin plays an important role in low frequency EAA. Meanwhile, this suggests us a probable route for potentiating acupuncture analgesia in clinical practice.

关 键 词：电针 止痛 脑啡肽酶 大鼠 

分 类 号：R245.97[医药卫生—针灸推拿学]