小剂量多巴胺联合前列地尔治疗慢性肾功能不全临床研究  

Clinical research of treatment of chronic renal failure with low-dose dopamine combined with alprostadil

作　　者：曹磊[1] 罗红[1] 

机构地区：[1]安徽省蚌埠市第三人民医院肾泌科,233000

出　　处：《淮海医药》2012年第1期31-33,共3页Journal of Huaihai Medicine

摘　　要：目的观察小剂量多巴胺联合前列地尔(pG1)治疗肾功能不全(CRF)的疗效。方法将100例CRF患者随机分为治疗组50例和对照组50例。治疗组给予小剂量多巴胺联合前列地尔治疗;对照组丹参注射液,共同给予低蛋白饮食,控制血压纠正贫血及对症治疗。观察治疗前后血浆肌酐(Scr),尿素(BUN)水平,内生肌酐清除率,24 h尿量,24 h尿蛋白定量等指标。结果治疗组慢性肾功能不全患者的血尿素、肌酐较对照组明显下降,尿量增加(P<0.05),Ccr较对照组明显升高,前列地尔差异有显著性(P<0.0 5),2组24 h尿蛋白定量均无明显变化。结论小剂量多巴胺联合前列地尔能有效延缓CRF进展。Objective To observe the effect of low-dose dopamine combined with alprostadil in the treatment of chronic re- nal failure （CRF）. Methods 100 patients with CRF were randomly divided into a treatment group （50 cases） and a control group （50 cases）. The treatment group received low-dose dopamine combined with alprostadil;the control group were treated with Salvia. The two groups were given low-protein diet, and anemia and blood pressure were controled. Indexes before and after treatment such as serum creatinine （Scr）,blood urea nitrogen（BUN） , endogenous creatinine clearancerate （ Ccr） ,24 h urine output, and 24h urine protein were measured and observed. Results In the treatment group,Scr and BUN decreased signifi- cantly compared with the control group while urine output increased（ P 〈 0.05） ,but Ccr was remarkably higher than the con- trol group. The difference was significant （ P 〈 0.0 5 ）. There was no significant difference between the two groups in terms of 24 h urinary nrotein. Conclusion Combination of low-dose dopamine with alprostadil is effective in the treatment of CRF.

关 键 词：肾功能不全 慢性 多巴胺 前列地尔 

分 类 号：R692.5[医药卫生—泌尿科学]