HIV与HCV间相互作用的研究现状  

Current status of the study on interaction between HIV and HCV

作　　者：洪国祜[1] 毛青[1] 

机构地区：[1]第三军医大学西南医院全军感染病研究所,重庆400038

出　　处：《传染病信息》2011年第6期324-328,共5页Infectious Disease Information

基　　金：国家"十一五"科技重大专项(2008ZX10001-008)

摘　　要：HIV和HCV合并感染较为常见,合并感染发生后这二种病毒在体内存在一定的相互作用,包括免疫细胞介导的间接作用和二种病毒感染同一细胞后产生的直接作用。此前在某些问题上学术界已经取得了较为一致的结论,认为HIV可以促进HCV复制,并抑制机体对HCV的清除作用。但近年亦有研究发现,机体内HCV载量与是否合并HIV感染无关,且HCV和HIV合并感染对机体自发清除HCV的能力无显著影响。上述相互矛盾的研究结果提示,HIV与HCV之间可能存在许多尚未明确的联系,应进一步从临床和基础两方面进行深入探讨。HIV and HCV coinfection is extremely prevalent worldwide.There are definitely interactions between those two viruses,including indirect effect mediated by immune cells and direct effect produced by the concurrent infection with HIV and HCV in the same cell.Consistent conclusion has been reached that HIV can enhance the replication of HCV and decrease the clearance capacity of HCV mediated by both intrahepatic and extrahepatic immune cells.However,recent studies have shown that the internal average HCV viral load is not associated with whether coinfection with HIV and HCV occurs,and HIV and HCV coinfection has little effect on spontaneous clearance of HCV.The confusion about the complicated interactions of HIV and HCV occurring in the host has suggested that there are indefinite associations between HCV and HIV,which requires more deep-going basic and clinical researches.

关 键 词：HIV 丙型肝炎病毒 病毒复制 

分 类 号：R373.51[医药卫生—病原生物学] R373.21[医药卫生—基础医学]