盐酸氨基葡萄糖治疗腰椎关节突关节骨性关节炎的临床观察  

Clinical Observation on Glucosamine Hydrochloride Treating Lumbar Zygapophyseal Joint Osteoarthritis

作　　者：张施展[1] 蒋林[1] 

机构地区：[1]武汉市中心医院骨科,武汉430014

出　　处：《华西医学》2011年第12期1832-1835,共4页West China Medical Journal

摘　　要：目的观察盐酸氨基葡萄糖治疗腰椎关节突关节骨性关节炎(lumbar zygapophyseal jointosteoarthritis,LZOA)的临床疗效及安全性。方法 2009年1月2010年1月,对90例LZOA患者随机分成治疗组和对照组,各45例。治疗组口服盐酸氨基葡萄糖,6周为1个疗程,治疗3个疗程,前2周均加用洛索洛芬钠;对照组患者仅给予洛索洛芬钠口服12周。比较两组治疗后2、6周及3、6、12个月的疗效及安全性。结果治疗后6周、3个月,治疗组与对照组症状均明显改善,对照组改善更明显。治疗6个月后,治疗组评分持续下降,到12个月时与治疗前比较差异有统计学意义(P<0.01);而对照组评分则逐渐增高,到12个月时与其治疗前比较差异无统计学意义(P>0.05)。两组的不良反应率分别为6.67%、15.56%,差异有统计学意义(P<0.01)。结论盐酸氨基葡萄糖治疗LZOA疗效确切,且安全性良好。Objective To observe the clinical efficacy and safety of glucosarnine hydroehloride on lumbar zygapophyseal joint osteoarthritis （LZOA）. Methods From January 2009 to January 2010, 90 patients with LZ（）A were randomly divided into therapeutic group and comparative group, with 45 patients in each group. Patients in therapeutic group were treated with oral administration of glucosarnine hydrochloride for 3 courses （6 weeks for one course; adding loxoprofen for the early 2 weeks）. Patients in comparative group were treated with oral administration of loxoprofen for 12 weeks. The efficacy and safety between the two groups was compared. Results Symptoms in both group were relieved after 6-week and 3-month treatment. More obvious relief was observed in the comparative group. The scoring of therapeutic group kept decreasing after 6-rnonth treatment. The efficacy showed significant improvement after 12-month treatment compared with which before the treatment was significant （P〈. 01）. The scoring in comparative group kept increasing, which showed no significant difference after 12-rnonth treatment（P〉 0.05）. The adverse effect rate was 6. 67% and 15. 56%respectively in two groups, which was significant different （P〈. 01）. Conclusions Glucosamine hydrochloride provides good efficacy and safety for patients with LZO.

关 键 词：盐酸氨基葡萄糖 腰椎关节突关节 骨性关节炎 

分 类 号：R684.3[医药卫生—骨科学] R97[医药卫生—外科学]