氟氯交换氟化合成对氟苯甲醛  

Synthesis of 4-Fluorobenzaldehyde by F-Cl Exchange Fluorination

作　　者：吕早生[1] 余腾飞[1] 张琳涵[1] 赵金龙[1] 黄吉林[1] 胡亚[1] 

机构地区：[1]武汉科技大学化学工程与技术学院,湖北武汉430081

出　　处：《化学与生物工程》2012年第1期54-56,共3页Chemistry & Bioengineering

摘　　要：以对氯苯甲醛(PCAD)和氟化钾为原料、以硝基苯和环丁砜(TMSO2)为溶剂、以四苯基溴化(Ph4PBr)和四乙二醇二甲醚(C10H22O5)为复合催化体系,直接氟化制得对氟苯甲醛。优化的工艺条件为:n(KF)∶n(PCAD)∶n(Ph4PBr)∶n(C10H22O5)=4∶1∶0.15∶0.05、反应温度210℃、反应时间8h,在此条件下对氟苯甲醛的收率为88.2%、转化率为92.8%、选择性为95.1%。Using Ph4PBr and C10H22O5 as synergism catalyst,nitrobenzene and TMSO2 as synergism solvent,4-fluorobenzaldehyde was prepared by halogen-exchange fluorination of 4-chlorobenzaldehyde（PCAD） with spray-dried KF.The optimum reaction conditions were obtained as follows：n（KF）∶n（PCAD）∶n（Ph4PBr）∶n（C10H22O5）=4∶1∶0.15 ∶0.05,reaction temperature 210 ℃,reaction time 8 h.Under above conditions,4-fluorobenzaldehyde was obtained with 88.2% yield,92.8% conversion,95.1% selectivity.

关 键 词：复合溶剂 卤素交换氟化 对氟苯甲醛 

分 类 号：TQ224.5[化学工程—有机化工]