盐酸米诺环素原位凝胶的流变学研究  

Rheological Evaluation of Minocycline Hydrochloride in Situ Gel

作　　者：郜琪臻[1] 刘华丽[2] 魏静[2] 丁平田[2] 

机构地区：[1]中国医科大学附属第一医院药学部,辽宁沈阳110001 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《化学与生物工程》2012年第1期63-65,共3页Chemistry & Bioengineering

摘　　要：采用振荡模式考察了盐酸米诺环素原位凝胶体系的流变学性质。结果表明,盐酸米诺环素原位凝胶溶液态为一种假塑性流体,非牛顿流体;原位凝胶遇水后弹性模量、粘性模量及复数粘度增大,而相角减小,原位凝胶中的高分子材料分散状态改变,发生时间依赖性的相转变。该体系为一种溶剂敏感型原位凝胶。The oscillatory measurement was used to study rheological properties of minocycline hydrochloride in situ gel.Results showed that minocycline hydrochloride in situ gel solution was a pseudo-plastic fluid,but not a Newtonian fluid.When in situ gel contacted with water,the elastic modulus,viscous modulus and complex viscosity increased,the phase angle decreased,the dispersion state of polymer changed and the occurrence of phase transition was time-dependent.It was deduced that minocycline hydrochloride in situ gel was a solvent sensitive system.

关 键 词：盐酸米诺环素 原位凝胶 流变学 

分 类 号：O648.17[理学—物理化学] R944.9[理学—化学]