复方大黄制剂联用治疗肿瘤患者化疗引起皮肤毒性反应的临床疗效研究  

The clinical research of Compound Rhubarb combination treatment on skin toxic reaction caused by chemotherapy in tumor patients

作　　者：刘兴 金德芹 

机构地区：[1]山东临沂肿瘤医院,山东临沂276001

出　　处：《齐鲁药事》2012年第1期45-47,共3页qilu pharmaceutical affairs

摘　　要：目的探讨复方大黄制剂联用,治疗化疗药物外渗引起的皮肤毒性反应的临床治疗效果.方法①治疗组50例,采用自制复方大黄制剂(冰块、药液、酊剂)联合使用,治疗3～7d.②对照组A组30例,采用单纯冰敷+0.1%利多卡因5mL+地塞米松5mg做环形皮下局部注射,一天两次,连续3d;对照组B组30例,单纯冰敷+外用海普林软膏,连用7d.结果治疗组有效率为98.0%;对照组A组有效率86.7%;B组有效率80.0%,治疗组与对照组A、B组比较存在明显差异(P<0.05).结论复方大黄制剂联用,是目前治疗肿瘤患者化疗引起皮肤毒性反应的有效方法之一.该方法具有经济、方便、高效、不良反应低等优点,值得临床广泛推广使用.Objective To investigate the clinical effects of Compound Rhubarb combination treatment on skin toxic reaction caused by chemotherapeutics exosmosis. Methods ①50 patients in treatment group received self - made Compound Rhubarb （ ice cubes ,liquid medicine, tincture） combination treatment for 3 - 7 days. ②30 patients in control group A received simple ice compress and circular hypodermic localized injection of 5 mL 0.1% lidocaine and 5 mg dexamethasone twice a day for 3 days. 30 patients in control group B received simple ice compress and external treatment of heparin sodium cream for 7 days. Results The effective rates were 98.0% of treatment group,86.7% of control group A and 80.0% of control group B, and there were significant differences （ P 〈 0. 05 ） between treatment group and control group A, B. Conclusion Compound Rhubarb combination treatmerit was an effective method for skin toxic reaction caused by chemotherapy in tumor patients. This method was economic, convenient and efficient with low adverse reaction rate, and it was worth to be widely promoted and applied in clinic.

关 键 词：复方大黄制剂 化疗 药物外渗 皮肤毒性反应 治疗 

分 类 号：R969.4[医药卫生—药理学]