尖山橙中生物碱类成分的研究  

Alkaloids in Melodinus fusiformis

作　　者：周长江[1,2] 关焕玉[2] 张援虎[2] 徐冉[2] 郝小江[2] 杨小生 

机构地区：[1]贵州师范大学化学与材料科学学院,贵州贵阳550001 [2]贵州省中国科学院天然产物化学重点实验室,贵州贵阳550002

出　　处：《中成药》2012年第1期85-89,共5页Chinese Traditional Patent Medicine

基　　金：贵州省民族药公共技术服务平台(黔发改投资[2007]1712号)

摘　　要：目的研究尖山橙中的生物碱类成分。方法干燥粉碎尖山橙全草用盐酸冷浸,浸液通过强酸型离子树脂后,用氨水碱化,晾干,再用95%乙醇洗脱浓缩得浸膏。应用硅胶、Sephadex LH-20、Rp-18柱色谱进行分离、纯化,根据理化性质和光谱分析鉴定化合物结构。结果从尖山橙中分离鉴定了9个生物碱类成分,分别为tabersonine(Ⅰ),11-hydroxytabersonine(Ⅱ),venalstonidine(Ⅲ),pachysiphine(Ⅳ),venalstonine(Ⅴ),scandine(Ⅵ),10-hydroxyscandine(Ⅶ),scandine Nb-oxide(Ⅷ)和5-methoxystrictamine(Ⅸ)。结论 化合物Ⅲ、Ⅳ、Ⅸ为首次从尖山橙中分离鉴定,其中化合物Ⅸ是首次从山橙属植物中分离鉴定。AIM To study the alkaloids in Melodinus fusiformis.METHODS The dried herbs of Melodinus fusiformis were immersed with HCl,after the enchyma passes the strong ion resin,was alkalified with ammonia solution,dried,then eluting with 95% ethanol,condense to gain extraction.Silica gel,Sephadex LH-20,Rp-18 Column were used to isolate and purify the constituents,and their structures were identified by spectral analysis and their physical characters.RESULTS Nine compounds were isolated from Melodinus fusiformis,and identified as tabersonine（Ⅰ）,11-hydroxy-tabersonine（Ⅱ）,venalstonidine（Ⅲ）,pachysiphine（Ⅳ）,venalstonine（Ⅴ）,scandine（Ⅵ）,10-hydroxy-scandine（Ⅶ）,scandine Nb-oxide（Ⅷ） and 5-methoxy-strictamine（Ⅸ）.CONCLUSION Compounds Ⅲ,Ⅳ,Ⅸ are isolated from Melodinus fusiformis for the first time,and compound Ⅸ is isolated from the plants of Melodinus for the first time.

关 键 词：尖山橙 山橙属 生物碱类成分 

分 类 号：R284.1[医药卫生—中药学]