毛细管色谱法测定盐酸米多君中的有机溶剂残留量  

Determination of residual organic solvents in midodrine hydrochloride by capillary gas chromatography

作　　者：安明[1] 赵国君[2] 王国成[3] 陈莹[3] 

机构地区：[1]包头医学院药学院,内蒙古包头014060 [2]包头市第四医院药剂科,内蒙古包头014030 [3]天津天士力集团研究院,天津300402

出　　处：《沈阳药科大学学报》2012年第2期136-138,共3页Journal of Shenyang Pharmaceutical University

摘　　要：目的建立毛细管气相色谱法测定盐酸米多君中的有机溶剂残留量。方法用HP-FFAP毛细管气相色谱柱,FID检测器,以正丙醇为内标进行测定。结果乙醇、乙腈、乙酸的线性范围分别为20～800μg.L-1(r=0.999 9)、1.64～65.6μg.L-1(r=0.999 7)、20～800μg.L-1(r=0.999 5),平均回收率分别为100.2%、99.7%、99.6%,RSD分别为0.74%、1.17%、1.37%(n=9)。结论本方法简单、准确、灵敏度高、重现性好,适用于盐酸米多君中有机溶剂残留量的测定。Objective To develop a gas chromatography method for the determination of residual organic solvents in midodrine hydrochloride. Methods The samples were injected into HP-FFAP capillary column and analyzed with FID detector using n-propanol as the internal standard. Results The linear ranges of ethanol, acetonitrile and acetic acid were 20- 800 μg·L^-1 （ r = 0. 999 9 ）, 1.64- 65.6μg·L^-1（ r = 0. 999 7 ）, 20- 800μg·L^-1 （ r = 0. 999 5 ）, respectively; the recoveries were 100. 2%, 99.7% and 99.6% with RSD of 0. 74 %, 1.17 % and 1.37 % （ n = 9 ）, respectively. Conclusions The method is simple, accurate and sensitive with good reproducibility. It can be used for the determination of the residual organic solvents in midodrine hydrochloride.

关 键 词：盐酸米多君 毛细管气相色谱法 有机溶剂残留量 

分 类 号：R917[医药卫生—药物分析学]