布地奈德/福莫特罗粉吸入治疗对支气管哮喘患者肺功能改善作用及血清细胞因子的影响  

Influence of budesonide and formoterol inhaling in improvement of pulmonary function and serum cytokines in patients with bronchial asthma

作　　者：唐颖[1] 丛中凰[1] 李晓丹[1] 许力军[1] 

机构地区：[1]吉林大学第一医院呼吸内科,吉林长春130021

出　　处：《吉林大学学报（医学版）》2012年第1期131-134,共4页Journal of Jilin University：Medicine Edition

基　　金：国家高技术研究发展计划(863计划)项目资助课题(2006AA02Z491)

摘　　要：目的:探讨细胞因子IFN-γ、IL-33、IL-17与支气管哮喘的关系,观察布地奈德/福莫特罗粉吸入治疗对支气管哮喘患者肺功能改善及上述细胞因子的影响。方法:选择确诊为中度哮喘急性发作患者40例,根据患者意愿分为常规组和吸入组各20例,健康对照20例。常规组采用常规治疗;吸入组在常规治疗基础上给予布地奈德160μg+福莫特罗4.5μg,每日2次吸入,疗程均为2周。测定治疗前后患者血清IL-33、IL-17、IFN-γ水平及肺功能情况,比较哮喘患者与健康对照组各项指标差异及两组患者治疗前后各项指标改善情况。结果:治疗前常规组和吸入组患者血清IL-33、IL-17、IFN-γ水平均高于对照组(P<0.05),PEF和FEV1/FVC均低于常规组(P<0.05)。常规组和吸入组患者治疗后血清IL-33、IL-17水平低于治疗前(P<0.05),PEF和FEV1/FVC高于治疗前(P<0.05);治疗后吸入组血清IL-33、IL-17水平低于常规组(P<0.05),PEF和FEV1/FVC高于常规组(P<0.05)。常规组和吸入组患者治疗前后血清IFN-γ水平差异无统计学意义(P>0.05)。结论:IFN-γ、IL-33、IL-17水平在哮喘患者体内明显增高,布地奈德/福莫特罗粉吸入剂可有效降低IL-33、IL-17水平,改善肺功能。Objective To investigate the realationship between IFN-γ,IL-17,IL-33 and bronchial asthma,and observe the influence of budesonide and formoterol treatment in the cytokines mentioned above and pulmonary function in the patients with bronchial asthma.Methods 40 patients who were diagnosed as moderate asthma with acute onset were divided into two groups：general treatment group and budesonide and formoterol inhaling treatment group,with 20 patients in each group.20 healthy adults were selected as control group.The patients in general treatment group were treated with antibiotics and aminofilina for 2 weeks,while the patients in inhaling treatment group were given general treatment and budesonide and formoterol inhaling.The levels of IFN-γ,IL-17,IL-33 and pulomanry function were detected,and then the indexes were compared among three groups including before and after treatment.Results The levels of IFN-γ,IL-17 and IL-33 in general treatment group and inhaling treatment group before treatment were higher than those in control group（P0.05）,but the PEF and FEV1/FVC were lower（P0.05）.After treatment the levels of IL-33 and IL-17 in inhaling treatment groups were decreased than before treatment（P0.05）,but the PEF and FEV1/FVC were increased（P0.05）;the levels of IL-33 and IL-17 in treatment group were lower after treatment than those in general treatment group,but the PEF and FEV1/FVC were higher.No statistical significance in the level of IFN-γ was found between before and after treatment in general treatment group and inhaling treatment group.Conclusion The levels of IFN-γ,IL-17 and IL-33 are significantly increased in patients with bronchial asthma;budesonide and formoterol inhaling can decrease the levels of IL-17 and IL-33,and improve the pulmonary function.

关 键 词：布地奈德 福莫特罗 支气管哮喘 白细胞介素-33 白细胞介素-17 γ-干扰素 肺功能 

分 类 号：R562.2[医药卫生—呼吸系统]