生物防御用DNA疫苗  

DNA vaccines used for biodefense

作　　者：刘文宇[1] 朱晓斐[1] 戚中田（综述）[1] 

机构地区：[1]第二军医大学微生物学教研室,上海市医学生物防护重点实验室,上海200443

出　　处：《国际生物制品学杂志》2011年第6期300-303,317,共5页International Journal of Biologicals

基　　金：国家传染病重大专项课题（2008ZX10002-013,2009ZX10004-106）

摘　　要：近年的生物防御疫苗研究集中于DNA疫苗。DNA疫苗对人以及环境相对安全、经济，并且多价联合DNA疫苗还可以提供多重保护，因此有良好的研发前景和潜在的实用价值，但也存在免疫原性不强和接种方式有待改进等问题。此文就炭疽杆菌、埃博拉病毒、马尔堡病毒、猴痘病毒、天花病毒和委内瑞拉马脑炎病毒等几种被美国NIH和CDC列为重要生物战剂的DNA疫苗研发现状作一综述。Most of the recent biodefense work has been focused on developing DNA vaccines, which are safe to both human and environment and cost-effective, and delivery of the combined DNA vaccines can offer the potential for multiple protection. Consequently, the DNA vaccines have good prospects for research, development and applications, but their immunogenicity and delivery methods remain to be improved. This review summarizes the research status of the DNA vaccines against several biodefense pathogens listed on both the NIH priority pathogen and CDC bioterrorism registries： Bacillus anthracis, Ebola and Marburg viruses, monkeypox virus, smallpox virus, and Venezuelan equine encephalitis virus.

关 键 词：疫苗 DNA 芽胞杆菌 炭疽 埃博拉病毒 马尔堡病毒 痘病毒科 甲病毒属 生物 防御 

分 类 号：R3[医药卫生—基础医学]