Tween80/异丙醇/丁酸乙酯/生理盐水体系微乳相结构及其作为姜黄素载体的研究  

Microstructure of Microemulsion as Curcumine Carrier Formed in Tween80/Isopropanol/Ethyl Butyrate/Normal Saline System

作　　者：王仲妮[1] 成朋[1] 李振[1] 鲁娟[1] 刁兆玉[1] 周武[1] 

机构地区：[1]山东师范大学化学化工与材料科学学院农药医药中间体清洁生产教育部工程技术中心,山东济南250014

出　　处：《食品与药品》2012年第1期16-20,共5页Food and Drug

基　　金：国家自然科学基金(31071603)

摘　　要：目的研究Tween80/异丙醇/丁酸乙酯/生理盐水体系的拟三元相图及其微乳相结构转变,并研究该体系的药物释放行为。方法用电导率法和循环伏安法测定微乳相结构转变。用紫外-可见分光光度计法测定姜黄素的溶解度,并探索水包油(O/W)型微乳载体中姜黄素的包封率和释放行为。结果研究表明,微乳结构在较低盐水浓度下形成油包水(W/O)型微乳,在中等盐水浓度转变为双连续型结构,在高盐水浓度连续转变为O/W型结构。O/W型微乳作为载体对姜黄素具有包封、增溶和缓释的作用。结论本实验中O/W型微乳对姜黄素具有一定的包封和缓释,鉴于体系的低毒性,期望对制药工业起到指导作用。Objective To study the pseudo-ternary phase diagram,the structural transformation and the drug release behavior of the tween80/isopropanol/ethyl butyrate/normal saline system.Methods The structural transformation was studied by cyclic voltammetric and conductivity measurements.The release behavior and entrapment efficiency of curcumine in the O/W microemulsion were measured by UV-Vis spectrophotometer.Results The structural transformation from a water-in-oil microemulsion at low salt content to a bicontinuous structure at intermediate salt content and a structure of oil-in-water at high salt content happened completely continuously.The O/W microemulsion as curcumine carrier produced encapsulation,solubilization and delayed release to curcumine.Conclusion Based on the relatively low toxicity and the solubilization and delayed release to curcumine,this O/W microemulsion can be expected to be used as a drug delivery system.

关 键 词：相图 微乳 姜黄素 包封 增溶 缓释 

分 类 号：R944.9[医药卫生—药剂学]